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News: Brain Tumors

Alex’s Lemonade grant allows new engineering grad student to join neuroblastoma fight

Monday, July 10th, 2017

A grant from cancer research nonprofit Alex’s Lemonade Stand Foundation is allowing a Vanderbilt chemical and biomolecular engineering doctoral student to join the fight against pediatric neuroblastoma. Kyle Garland is spending his summer on a project titled Immunotherapeutic Targeting of the STING Pathway to Combat Neuroblastoma. He’s working with John Wilson, assistant professor of chemical […]

Blocking neuroblastoma cell growth

Friday, March 24th, 2017

Neuroblastoma – a cancer that starts in nerve tissue outside of the brain – is the third most common cancer in children and accounts for about 15 percent of pediatric cancer-related deaths. MYC proteins drive neuroblastoma tumorigenesis in part by promoting the expression of key glycolytic enzymes such as LDHA to induce aerobic glycolysis (a […]

Proliferative capacity of neuroblastoma

Thursday, September 1st, 2016

Neuroblastoma is a neural crest cell-derived extracranial solid cancer that affects infants and young children. The most vigorous of these cancers spreads through self-renewing cancer stem cells. Knowing the nature of these cells is essential to understanding the progression of neuroblastoma and devising the right treatment strategy. Reporting in the journal Biochemical and Biophysical Research […]

Origins of neuroblastoma

Monday, August 24th, 2015

Neuroblastoma – a pediatric cancer of the sympathetic (“fight or flight”) nerve ganglia and adrenal glands – is thought to originate from the cells that give rise to the developing sympathetic nervous system. Amplification of the MYCN oncogene is associated with risk in this disease, but its role in the early steps of neuroblastoma initiation […]

New type of trial shows promise for several cancers

Monday, August 24th, 2015

Anti-cancer drugs are typically tested on one type of cancer at a time. But an international consortium of cancer investigators, including Vanderbilt-Ingram Cancer Center (VICC) researchers, simultaneously tested an existing therapy in patients with several different forms of cancer that all exhibit the same tumor gene mutation. The new clinical trial showed promising results in […]

Cancer signaling pathway blocker

Friday, April 10th, 2015

Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer. Abnormal regulation of this pathway leads to several human malignancies, including small cell lung cancer and pancreatic cancer, and therefore it is a potential drug target for cancer. Small molecules have […]

NCI report shows U.S. cancer deaths on decline

Thursday, April 2nd, 2015

The death rates for most forms of cancer continue to decline at a modest pace among men, women and children in the United States, according to the Annual Report to the Nation on the Status of Cancer 1975 – 2011. The report from the National Cancer Institute, a division of the National Institutes of Health, […]

New Method May Allow Personalized Clinical Trial for Cancer Therapies

Tuesday, August 14th, 2012

A new tool to observe cell behavior has revealed surprising clues about how cancer cells respond to therapy – and may offer a way to further refine personalized cancer treatments. The approach, developed by investigators at Vanderbilt-Ingram Cancer Center, shows that erlotinib – a targeted therapy that acts on a growth factor receptor mutated in […]

Study Links Rare Genetic Marker to Brain Cancer

Friday, August 10th, 2012

Glioma is the most common and lethal type of brain tumor, and now investigators from Vanderbilt-Ingram Cancer Center and three other cancer centers have identified a link between a rare genetic variant and the risk of developing glioma. The variant also appears to improve the odds of survival among glioma patients. Reid Thompson, M.D., William […]

Network Approach Yields Glioblastoma Clues

Friday, August 10th, 2012

MicroRNAs (miRNAs) play key roles in cellular development, differentiation and cancer growth by regulating gene expression. They may be clinically useful as biomarkers and as targets for new drugs to treat such cancers as glioblastoma multiforme, the most common and lethal primary brain tumor in humans. But first scientists must understand better how the actions […]

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