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    News: Breast Cancer

    Chance to sing for the Pope motivates cancer patient

    Thursday, January 26th, 2017

    Cancer patient Sharon Edwards will lift her voice toward what she hopes is a better year when she sings for Pope Francis later this month. “I used to be a soprano until radiation turned me into an alto,” she said, attempting to hold back a tear with humor. She doesn’t always succeed. It’s hard not […]

    Targeting the “un-targetable”

    Thursday, December 1st, 2016

    Triple negative breast cancers (TNBC) are so named because they lack common genetic “target” mutations that can be easily treated with specific cancer drugs. However, in a recent study published in Molecular Cancer Therapeutics, Deborah Lannigan, Ph.D., and colleagues investigated a new target involved in TNBC called RSK. They demonstrated that RSK can help cancers […]

    Screening mammograms now offered at four locations

    Thursday, October 13th, 2016

    One in eight women will be diagnosed with breast cancer in their lifetime and those cancers are often detected through screening mammograms. A mammogram is a low-dose X-ray of the breast that enables an imaging specialist to look for changes in breast tissue that could indicate cancer. The American Cancer Society, the National Comprehensive Cancer […]

    Breast imaging’s Huff dedicated to precision

    Thursday, September 29th, 2016

    A series of beautiful photographs of turquoise waves curling over a sandy beach sits above the desk of John Huff, M.D. An accomplished photographer whose work has been exhibited at shows in Nashville as well as regional invitational shows in Louisville, Birmingham, and the International Center for Photography in New York, Huff said most people […]

    BMI genotype and breast cancer risk

    Thursday, September 29th, 2016

    Being overweight is associated with decreased risk of breast cancer before menopause and increased risk after menopause. In a study published recently in PLOS Medicine, Wei Zheng, Ph.D., M.D., and colleagues investigate these contrasting associations. They use data from 145,056 women, and a list of genetic variants found in genomic studies to be associated with […]

    National Lymphedema Network honors VUMC research efforts

    Thursday, September 22nd, 2016

    Lymphedema research conducted at Vanderbilt University Medical Center (VUMC) to better understand patient risk for this chronic condition and treatment responses received recognition at an international conference. Paula Donahue, DPT, assistant professor of Physical Medicine and Rehabilitation, recently received Best Research Award in the new investigator category at the 2016 National Lymphedema Network Conference, which […]

    In search of new cancer targets

    Thursday, September 15th, 2016

    Molecularly heterogeneous cancers such as triple-negative breast cancer are challenging to treat, because they often lack the “driver” mutations that are targeted by the newest cancer therapies. These cancers exhibit genomic instability, resulting in chromosomal rearrangements and gene fusions, and identifying these alterations is technically difficult. Timothy Shaver and Brian Lehmann, Ph.D., working with Jennifer […]

    New breast cancer driver

    Friday, August 26th, 2016

    Approximately 20 percent of breast cancers have overexpression of the protein HER2, which drives signaling by the protein kinase Akt and is a marker of aggressive disease. The protein complex Rictor/mTORC2 is a known activator of Akt, but its role in breast cancer formation, progression and treatment is unclear. Rebecca Cook, Ph.D., and colleagues have […]

    Breast cancer: finding the smoking gun

    Thursday, July 21st, 2016

    Many genes are associated with cancer. The trick is proving they actually promote tumor formation. One approach, detailed by Ian Macara, Ph.D., and colleagues last month in Cell Reports, is an in vivo “gain-of-function” screen. The researchers used a gene “library” (complementary DNA carried by lentivirus) to increase the expression of nearly 1000 different genes […]

    Idrees receives award for cancer outcomes research

    Thursday, July 7th, 2016

    Kamran Idrees, M.D., MSCI, assistant professor of Surgery, has received a Young Investigator Award from the Society of Surgical Oncology Foundation (SSO). The award supports innovative concepts designed to improve health outcomes through advances in the delivery of care. Idrees, who joined the Vanderbilt faculty in 2012, said the one-year award “was an unexpected honor […]

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