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News: Breast Cancer

VICC investigators land support from Komen Foundation

Tuesday, October 3rd, 2017

Three breast cancer investigators from Vanderbilt-Ingram Cancer Center (VICC) have been awarded research grants from Susan G. Komen, a nonprofit foundation devoted to supporting cancer research, community health outreach, advocacy and public policy initiatives.

Are you a breast cancer survivor?

Friday, September 22nd, 2017

Health & Wellness would like to celebrate you and support breast cancer awareness by creating an “Awareness Saves Lives” faculty and staff survivor banner. The banner will be displayed as part of the 2017 Breast Cancer Awareness Expo scheduled for Oct. 4 from 11 a.m. to 1 p.m. in the Light Hall North Lobby.

Breast Cancer Genomic Profiling Reveals Clues to Treatment Resistance

Friday, August 11th, 2017

Thanks to advances in treatment, the relative five-year survival rate from all combined subtypes of breast cancer now exceeds 90 percent and yet the disease remains the third leading cause of cancer deaths in the United States after lung and colorectal cancers. Carlos L. Arteaga, M.D. More than 40,000 American women will die from breast […]

Stress may switch on bone “mets”

Friday, August 11th, 2017

Stress stimulates the formation of blood vessels in bone and may help breast cancer cells to invade this organ. In the July issue of the Journal of Bone and Mineral Research, Florent Elefteriou, Ph.D., Julie A. Sterling, Ph.D., and colleagues describe a mechanism for skeletal colonization by breast cancer cells that could lead to new ways to […]

Investigators match novel cancer mutations with potential therapies

Monday, August 7th, 2017

Research led by Vanderbilt-Ingram Cancer Center (VICC) investigators may have solved a mystery about why a targeted therapy stops working in a small group of breast cancer patients. They identified a novel gene mutation that develops in the tumors, and then found a different cancer drug that appears to treat the newly identified mutation. The […]

Drivers of breast cancer metastasis

Thursday, July 27th, 2017

Overexpression of HER2 (human epidermal growth factor receptor 2) is found in about 25 percent of breast cancers and is associated with poor outcomes. HER2-amplified breast cancers use signaling through a complex of proteins called mTORC2 to drive tumor formation, tumor cell survival and resistance to HER2-targeted therapies. Rebecca Cook, Ph.D., and colleagues have now […]

Study identifies protein’s role in chemotherapy resistance

Friday, July 21st, 2017

Researchers at Vanderbilt University Medical Center (VUMC) have discovered a protein that may lead to a new way to prevent resistance and improve outcomes for patients whose cancers have mutations in the tumor suppressor gene BRCA2. The protein, RADX, is a DNA-binding protein. It regulates the activity of an enzyme called RAD51, which helps repair tumor-promoting […]

Arteaga to direct UT Southwestern cancer center

Thursday, July 13th, 2017

Carlos L. Arteaga, M.D., director of the Center for Cancer Targeted Therapies (C2T2), director of the Breast Cancer Research Program and associate director for Clinical Research at Vanderbilt-Ingram Cancer Center (VICC), has been named director of the Harold C. Simmons Comprehensive Cancer Center and associate dean of Oncology Programs at the UT Southwestern Medical Center […]

VICC experts to discuss high risk breast cancer at free seminar June 6

Friday, May 26th, 2017

Vanderbilt-Ingram Cancer Center (VICC), in collaboration with the Hereditary Cancer Program and the Vanderbilt Breast Center, will host a free seminar, “Are You at High Risk for Breast Cancer?” This interactive program to be held Tuesday, June 6, 5:30 – 7:30 p.m., at Vanderbilt Health One Hundred Oaks, 719 Thompson Lane, is open to anyone […]

Polarity protein role in cell survival

Thursday, April 27th, 2017

Cell survival is dependent upon regulation of numerous proteins, both cytosolic and membrane bound. Reporting in Nature Communications, Mukhtar Ahmed, Ph.D., and Ian Macara, Ph.D., identified an unexpected link between cell survival and the polarized delivery of proteins to the surface of mammary epithelial cells. The Par3 protein plays a central role in polarity. It […]

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