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    News: Cancer Research

    New targeted therapy shows promise for rare joint tumor

    Friday, August 7th, 2015

    Vanderbilt-Ingram Cancer Center (VICC) investigators and colleagues at several major medical centers have been testing a new targeted therapy that is showing promise for the treatment of a rare tumor that forms in and around joint cavities. The study was published in the July 30 issue of The New England Journal of Medicine. Tenosynovial giant-cell […]

    Stomach cancer cues

    Friday, August 7th, 2015

    Stomach cancer is one of the most frequent cancers in the world and does not usually respond well to current treatments. Understanding how stomach cancer develops could provide new opportunities for treatment. Reporting last month in the journal Oncogene, Wael El-Rifai, M.D., Ph.D., and colleagues have discovered a new molecular mechanism involving the protein DARPP-32 […]

    Brown to head cancer registry for Y-90 tumor treatments

    Thursday, July 30th, 2015

    Dan Brown, M.D., professor of Radiology and Radiological Sciences and chief of Interventional Oncology, will spearhead a national Vanderbilt-led research registry that tracks cancer patients whose tumors are treated with Yttrium-90 (Y-90), a radioactive isotope. The Radiation-Emitting SIR-Spheres in Non-Resectable (RESIN) Liver Tumor Patient Registry is the result of a collaboration between VUMC, initially up […]

    Singer’s selfless gift benefits lung cancer program

    Thursday, July 30th, 2015

    In a town full of amazing singers, Nashville songstress Dawn Sears’ voice was something special. Among the music professionals who tour with superstars and perform in Nashville recording sessions, Sears was celebrated for a voice of crystalline purity. The “Dawn Sears and Friends” event, emceed by Olympic figure skater and cancer survivor Scott Hamilton, and […]

    Study sheds light on human gut’s ‘pacemaker’ cells

    Thursday, July 30th, 2015

    The gut has its own built-in pacemakers, populations of specialized cells that control smooth muscle contraction in the stomach, small intestine and colon. If these cells fail to develop or if they malfunction, digestion is slowed, nutrient absorption is impaired, and a wide range of gastrointestinal disorders can result. Now Vanderbilt University scientists have discovered […]

    Anticancer olive compounds

    Thursday, July 30th, 2015

    Natural compounds from plants – phytochemicals – provide a variety of health benefits, including anticancer activity. The human topoisomerases, enzymes that “detangle” DNA, are important targets for plant-derived anticancer drugs. To discover novel phytochemicals with anticancer activity, Kendra Vann, Neil Osheroff, Ph.D., and colleagues screened a library of 341 Mediterranean plant extracts for activity against […]

    Worldwide Cancer Research lauds Macara’s contributions

    Thursday, July 30th, 2015

    Ian Macara, Ph.D., professor and chair of the Department of Cell and Developmental Biology, recently returned from Scotland, where he received this year’s Colin Thomson Memorial Medal for his contributions to cancer research. Worldwide Cancer Research has funded nearly 2,000 research projects around the world since its establishment by Colin Thomson in 1979.The medal, sponsored […]

    Study sheds light on crucial DNA binding protein

    Thursday, July 30th, 2015

    Researchers at Vanderbilt University have established the molecular basis for the function of Replication Protein A (RPA), a DNA binding protein that is a crucial “scaffold” for genome replication, response to damage and repair. With colleagues at Yale University, they also determined that the small, highly charged protein DSS1 acts on RPA to function as […]

    Hyundai Hope On Wheels bolsters pediatric cancer fight

    Thursday, July 30th, 2015

    Debra Friedman, M.D., director of Pediatric Hematology/Oncology and E. Bronson Ingram Professor of Pediatric Oncology, has received a $50,000 Hyundai Hope On Wheels Impact grant recently for her track record in providing excellent patient care to families affected by pediatric cancer and to support a pediatric cancer program aimed at developing innovative therapies. Hyundai Hope […]

    Targeting bone metastasis

    Thursday, July 23rd, 2015

    Many common cancers spread, or metastasize, to the bone. As these metastases destroy bone and are incurable, understanding the underlying molecular mechanism could provide new opportunities for treatment. Julie A. Sterling, Ph.D., Scott Guelcher, Ph.D., and colleagues in the Center for Bone Biology tested the hypothesis that the bone microenvironment, specifically the rigid mineralized extracellular […]

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