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    News: Cancer Research

    Investigators find clues to melanoma treatment resistance

    Friday, October 30th, 2015

    Nearly half of all patients with malignant melanoma, the most deadly form of skin cancer, have a mutation in the BRAF gene found in their tumors. Mutations in the BRAF gene turn on a cancer growth switch known as the MAP kinase pathway. In recent years, new drugs have been approved that target the BRAF/MAPK […]

    VUMC and Incyte Corp. form new scientific alliance

    Thursday, October 22nd, 2015

    Vanderbilt University Medical Center (VUMC) investigators have joined forces with scientists at Incyte Corp. to explore new therapies for the treatment of various types of cancer, as well as other diseases. The company has agreed to help fund basic and translational science research by VUMC investigators. Incyte Corp. is a Wilmington, Delaware-based biopharmaceutical company focused […]

    Biomarker for intestinal tumors

    Thursday, October 22nd, 2015

    The incidence of pancreatic and small intestinal neuroendocrine tumors (NETs) has risen over the past decade. NETs are the second most common cancers in the small intestine and pancreas and are frequently associated with liver metastasis. Safia Salaria, M.D., and colleagues examined expression of CD24 – a biomarker for normal and cancer stem cells – […]

    New faculty: Bethany Rhoten examines quality of life among cancer survivors

    Monday, October 19th, 2015

    Bethany Rhoten’s research focuses on issues that few people openly discuss—those surrounding body image and sexuality among cancer survivors. “While conducting research for my dissertation, I saw how difficult it is when a patient with head and neck cancer looks in the mirror and the person they see is not the person they saw six […]

    Study shows compression device helps ease lymphedema

    Friday, October 9th, 2015

    Lymphedema patients saw a nearly 80 percent reduction in cellulitis episodes by using an advanced pneumatic compression device at home, according to a study in JAMA Dermatology co-authored by Vanderbilt University School of Nursing’s Sheila Ridner, Ph.D., and University of Minnesota School of Public Health Associate Professor Pinar Karaca-Mandic, Ph.D. The reduction in episodes also led […]

    Potential target for lung cancer therapy

    Friday, October 9th, 2015

    A protein that transports the amino acid glutamine is a potential biomarker and therapeutic target for non-small cell lung cancer, Vanderbilt researchers reported in the Oct. 1 International Journal of Cancer. Pierre Massion, M.D., and colleagues previously demonstrated that the protein SLC1A5 is the primary transporter of glutamine – a modulator of cell growth and oxidative […]

    Komen, VICC partnership bolsters breast cancer research

    Friday, October 9th, 2015

    For more than twenty years, Vanderbilt-Ingram Cancer Center’s (VICC) primary source of outside funding has been provided by the National Institutes of Health. But in breast cancer, Susan G. Komen, a nonprofit dedicated to breast cancer research and community services, has been a significant sponsor of research and patient care support. Komen has provided more […]

    Five VUMC faculty members on list of most frequently cited researchers

    Friday, October 9th, 2015

    Five current faculty members at Vanderbilt University Medical Center have made this year’s list of scientists whose papers have been cited most frequently by others. The metric, developed by the global information giant Thomson Reuters, has become a prominent measure of a scientist’s influence on his or her field of endeavor. This year 3,125 scientists […]

    Collaboration seeks to develop new therapies for bone, other diseases

    Thursday, October 1st, 2015

    Drug discovery efforts that started in zebrafish are moving closer to clinical development. La Jolla Pharmaceutical Co. and Vanderbilt University have signed a research and license agreement covering Vanderbilt’s research program and intellectual property rights related to compounds that block bone morphogenetic protein (BMP) type-I receptors. The compounds have therapeutic potential in a broad range […]

    Reduced-nicotine cigarettes decreased dependence and frequency of smoking

    Thursday, October 1st, 2015

    Reduced-nicotine cigarettes were beneficial in reducing nicotine exposure and dependence, and also the number of cigarettes smoked per day, when compared with standard-nicotine cigarettes in a six-week study published in the New England Journal of Medicine. It is the first large-scale clinical trial to examine the effects of reduced-nicotine cigarettes on smoking behavior and exposure […]

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