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News: Cancer Research

Mutations may predict melanoma response to immunotherapies

Thursday, March 12th, 2015

Melanoma patients whose tumors test positive for mutations in the NRAS gene were more likely to benefit from new immunotherapy drugs, according to a new study led by Vanderbilt-Ingram Cancer Center (VICC) investigators. Douglas Johnson, M.D., assistant professor of Medicine, and Christine Lovly, M.D., Ph.D., assistant professor of Medicine and Cancer Biology, are co-first authors […]

‘Cancer: The Emperor of All Maladies’

Wednesday, March 11th, 2015

The Vanderbilt-Ingram Cancer Center, in collaboration with Nashville Public Television, American Cancer Society, and Gilda’s Club, will host a free preview of “Cancer: The Emperor of All Maladies,” panel discussion and moderated Q&A on Wednesday, March 25 at the Vanderbilt University Student Life Center.

Zanic’s journey to lab followed winding path

Monday, March 9th, 2015

It’s roughly 5,000 miles from Croatia to Tennessee as the crow flies. For Marija Zanic, Ph.D., who joined Vanderbilt University’s Department of Cell and Developmental Biology as an assistant professor last August, the journey from her home country took a more circuitous route — from cell biology to theoretical physics and back again. Zanic’s dissertation […]

Grant boosts head and neck lymphedema research

Monday, March 9th, 2015

Vanderbilt University School of Nursing (VUSN) has been awarded a four-year, $2.4 million grant from the National Institutes of Health/National Institute of Dental and Craniofacial Research to establish a valid, clinically useful measurement battery for head and neck lymphedema and fibrosis (LEF). Principal investigator Jie Deng, Ph.D., R.N., developed the proposal because she commonly sees […]

‘Stretched’ cells promote cancer

Thursday, February 26th, 2015

Interactions between tumor cells and other cell types in the surrounding microenvironment (stroma) are crucial for tumor cell growth, survival and metastatic spread. Although tumor cells are known to induce mechanical changes in their microenvironment, few studies have examined the effect of mechanical stimuli on stromal cells such as fibroblasts. Donna Webb, Ph.D., Deyu Li, […]

Antibiotics with anticancer potential

Thursday, February 26th, 2015

The type II topoisomerases – enzymes that manage tangles and supercoils in DNA – exist in all organisms and are important drug targets. Widely prescribed anticancer agents including etoposide and doxorubicin target human type II topoisomerases, and quinolone antibiotics such as ciprofloxacin target bacterial topoisomerases. Clinically relevant quinolones have no activity against human type II […]

Cancer survival improvements vary by age, race

Thursday, February 26th, 2015

Improvements in cancer diagnosis and treatment have led to longer survival for most cancer patients in the United States. However, the improvement in survival was substantially greater among younger patients and those who are white in most of the cancers studied, according to new research by Vanderbilt University investigators. The study was published online recently […]

Gene profile predicts metastasis

Thursday, February 12th, 2015

Gene expression profiling has been applied to predict metastatic recurrence, the leading cause of deaths in patients with colorectal carcinoma. However, the biological mechanism is not completely understood, driving poor clinical outcomes. To address this issue, Dan Beauchamp, M.D., Bing Zhang, Ph.D., and colleagues analyzed the 11 human microarray datasets from 1,295 tumor specimens as […]

BlackHawk’s support reaches milestone

Thursday, February 12th, 2015

Country music group BlackHawk recently presented a check for $20,000 to Harold (Hal) Moses, M.D., Ingram Professor of Cancer Research and director emeritus of Vanderbilt-Ingram Cancer Center (VICC), in support of cancer research. Since 2006, the group has raised and donated $100,000 to VICC in remembrance of one of the original members of the multi-platinum […]

Grant bolsters Kirschner’s prostate cancer research

Thursday, February 5th, 2015

Austin Kirschner, M.D., Ph.D., assistant professor of Radiation Oncology and Cancer Biology, has received the Urology Care Foundation Research Scholars Award for the study of advanced prostate cancer. “I am very honored to receive this important award in support of research to help men with difficult-to-treat forms of prostate cancer,” said Kirschner, who joined the […]

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