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    News: Cancer Research

    Collaboration seeks to develop new therapies for bone, other diseases

    Thursday, October 1st, 2015

    Drug discovery efforts that started in zebrafish are moving closer to clinical development. La Jolla Pharmaceutical Co. and Vanderbilt University have signed a research and license agreement covering Vanderbilt’s research program and intellectual property rights related to compounds that block bone morphogenetic protein (BMP) type-I receptors. The compounds have therapeutic potential in a broad range […]

    Reduced-nicotine cigarettes decreased dependence and frequency of smoking

    Thursday, October 1st, 2015

    Reduced-nicotine cigarettes were beneficial in reducing nicotine exposure and dependence, and also the number of cigarettes smoked per day, when compared with standard-nicotine cigarettes in a six-week study published in the New England Journal of Medicine. It is the first large-scale clinical trial to examine the effects of reduced-nicotine cigarettes on smoking behavior and exposure […]

    Team to explore using nanoparticles to fight cancer

    Thursday, September 24th, 2015

    Three Vanderbilt researchers have received a federal grant to study the use of nanoparticles to deliver potential therapies for breast cancer that has spread to the bone. The grant from the Department of Defense Breast Cancer Research Program will provide more than $700,000 over three years in support of the research spearheaded by Julie Sterling, […]

    Cancer therapies’ impact on heart, kidneys explored

    Thursday, September 24th, 2015

    Vanderbilt is embarking on a multi-disciplinary approach to understand how promising cancer treatments, specifically certain kinase inhibitors, affect the heart and kidneys. In recent years, kinase inhibitors have emerged as important options for treating many cancers. In particular, specific kinase inhibitors, called angiogenesis (or VEGF) inhibitors, target the tumor vasculature and have become options for […]

    Bad “traffic” linked to cancer

    Thursday, September 3rd, 2015

    The epidermal growth factor receptor (EGFR) is activated in different locations in the cell by different proteins called ligands. Transporting ligands to the wrong places, called mistrafficking, is associated with abnormal signaling and cancer. Polarized columnar epithelial cells have an “apical” surface that faces the lumen, or body cavities, and a “basolateral” surface that faces […]

    Carr, Manning honored by radiology research academy

    Thursday, August 27th, 2015

    Two leaders in imaging science at Vanderbilt University are among 37 recipients of the 2015 Distinguished Investigator Award from the Academy of Radiology Research (ARR), academy officials announced last week. They are J. Jeffrey Carr, M.D., M.Sc., the Cornelius Vanderbilt Professor of Radiology and Radiological Sciences, and H. Charles Manning, Ph.D., Vanderbilt Ingram Associate Professor of […]

    Arteaga lauded for cancer research contributions

    Thursday, August 27th, 2015

    Carlos L. Arteaga, M.D., the Donna S. Hall Professor of Breast Cancer and director of the Center for Cancer Targeted Therapies and the Breast Cancer Program at Vanderbilt-Ingram Cancer Center (VICC), has been recognized for his cancer research efforts by the American-Italian Cancer Foundation (AICF). The AICF will also honor Frederick Alt, Ph.D., a Howard […]

    Drug combos enhance ovarian cancer cell death

    Monday, August 24th, 2015

    Ovarian cancer is often diagnosed at an advanced stage and frequently develops resistance to platinum chemotherapy. Identifying new drug combinations to overcome platinum resistance is a critical clinical challenge. They report in the Journal of Ovarian Research that combined thymoquinone and cisplatin had synergistic anti-tumor effects in cultured cells. The drug combination reduced tumor burden and […]

    Origins of neuroblastoma

    Monday, August 24th, 2015

    Neuroblastoma – a pediatric cancer of the sympathetic (“fight or flight”) nerve ganglia and adrenal glands – is thought to originate from the cells that give rise to the developing sympathetic nervous system. Amplification of the MYCN oncogene is associated with risk in this disease, but its role in the early steps of neuroblastoma initiation […]

    Study seeks to ease ‘chemobrain’ for cancer patients

    Monday, August 24th, 2015

    Many women who receive chemotherapy for breast cancer report problems with their thinking, memory and attention after treatment. And as the survival rates for breast cancer increase, so do these issues associated with chemotherapy. Paul Newhouse, M.D., professor of Psychiatry and Jim Turner Professor of Cognitive Disorders, and graduate student Jennifer Vega in Vanderbilt University […]

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