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    News: Cancer Research

    Study explores less invasive way to monitor colorectal cancer

    Monday, February 22nd, 2016

    Investigators at Vanderbilt University Medical Center have published research regarding an important feature of colorectal cancer (CRC) that could eventually lead to the development of non-invasive means of monitoring cancer progression. After lung cancer, CRC is the second-most lethal cancer in the United States. The team’s research, published in eLIFE, indicates that colorectal cancer cells […]

    Overcoming lung cancer drug resistance

    Thursday, February 11th, 2016

    Despite advances in diagnosis and treatment, lung cancer is the leading cause of cancer-related death. Many lung cancer patients have mutations in the proteins regulating cell growth, such as the epidermal growth factor receptor (EGFR). Tumors with EGFR mutations are initially extremely responsive to EGFR-specific tyrosine kinase inhibitors (TKIs). Unfortunately, tumors rapidly become resistant to […]

    Study identifies potential colon cancer biomarker

    Thursday, February 11th, 2016

    A protein that suppresses a key cancer pathway in the colon may be a potential biomarker for colitis-associated tumors, researchers at Vanderbilt University Medical Center reported last month in the journal Gut. The protein, called blood vessel epicardial substance or BVES, also may be a new therapeutic target for cancers in the colon and elsewhere, […]

    Prostate cancer survivors’ risk of heart disease studied

    Thursday, February 4th, 2016

    The 3 million prostate cancer survivors in the United States are likely to die from something other than cancer, thanks to early detection, effective treatment and the disease’s slow progression. What survivors need to be more concerned with is heart disease, the most common non-cancer cause of death for men with prostate cancer, according to […]

    Findings offer new insight on how cell division proteins work

    Thursday, January 28th, 2016

    A family of proteins with critical roles in cell division, synaptic transmission and cell migration don’t all function the way scientists thought they did, according to two new studies led by Vanderbilt researchers. Instead of bending membranes into tubes, these “F-BAR” proteins — named for a domain they share — appear to form patches on […]

    Study identifies new culprit in lung cancer development

    Thursday, January 28th, 2016

    A microRNA — a small piece of RNA involved in regulating gene expression — functions as an oncogene to drive the development of lung cancer, Vanderbilt University investigators have discovered. The microRNA, known as miR-31, is expressed at high levels in human lung adenocarcinoma, and its expression correlates with reduced patient survival, said Christine Eischen, […]

    VICC helps expand cancer patient’s treatment options

    Thursday, January 14th, 2016

    Edward (Ned) Wikle recently celebrated the Christmas holidays with his wife and three young children, a celebration the Jackson, Mississippi-based endodontist, U.S. Navy veteran and cancer patient wasn’t sure he would have. But research by Vanderbilt-Ingram Cancer Center (VICC) investigators and the discovery of a novel gene mutation in his tumor have given him more […]

    Copying chromosome caps

    Friday, January 8th, 2016

    DNA replication – the process of copying the DNA each time a cell divides – faces many sources of stress, such as DNA damage and sequences that are difficult to copy. A family of related enzymes, including SMARCAL1, responds to replication stress to stabilize, repair and restart stalled replication “forks.” David Cortez, Ph.D., and colleagues […]

    New lead for ovarian cancer treatment

    Friday, December 11th, 2015

    Despite increasingly advanced treatments, nearly half the women who contract ovarian cancer will die within five years. Chemotherapy drug resistance significantly contributes to the high mortality rate. Understanding the processes that trigger tumor growth allows scientists to find better ways to treat this disease. Members of the laboratory of Hal Moses, M.D., previously identified the […]

    Review highlights financial impact of sarcoma misdiagnosis

    Thursday, December 10th, 2015

    Malpractice awards and settlements are eight times greater when physicians misdiagnosis sarcoma than when they make other mistakes, according to a review of 32 years of court cases. For orthopaedic surgeons, the indemnity payments were 17 times higher. However, primary care physicians were more apt to be sued. The review is the latest effort by […]

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