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    News: Cancer Research

    Study examines new breast cancer drug combination

    Thursday, April 27th, 2017

    A study led by Vanderbilt-Ingram Cancer Center (VICC) investigators suggests a drug combination which includes a PDK1 protein blocker may be more effective for breast cancer that has become resistant to cyclin-dependent kinase (CDK4/6) targeted therapy. The study, published in Cancer Research, was led by first author Valerie Jansen, M.D., Ph.D., instructor in Medicine. Valerie […]

    VICC Annual Scientific Retreat slated for May 4

    Thursday, April 20th, 2017

    **Registration is now closed. For questions or to request late registration, please contact:  Lynnette M. Stanton-Williams phone: (615) 936-1374 lynnette.stanton-williams@vanderbilt.edu Leading cancer investigators from several prominent universities and laboratories will headline the 2017 Vanderbilt-Ingram Cancer Center (VICC) Annual Scientific Retreat. Clinicians, scientists, students, staff members and patients are invited to attend the free retreat to be […]

    A new mode of DNA repair

    Friday, April 14th, 2017

    DNA repair enzymes protect the genome from mutations that can lead to disease. Repair enzymes called DNA glycosylases were recently found to repair DNA interstrand cross-links (ICLs), highly toxic lesions formed by toxins and chemotherapeutic agents. To explore the mechanism for DNA glycosylase-catalyzed ICL removal, Brandt Eichman, Ph.D., and colleagues solved the X-ray crystal structure […]

    Horn to lead lung cancer combination therapy trial

    Sunday, April 2nd, 2017

    Leora Horn, M.D., M.Sc., associate professor of Medicine and clinical director of the Thoracic Oncology Program at Vanderbilt-Ingram Cancer Center (VICC), has been selected to lead a clinical research trial of combination therapy using two targeted drugs for the treatment of a specific form of lung cancer. The Phase 1/2 trial will test the drugs […]

    Nanobeacon lights up colon tumors

    Sunday, April 2nd, 2017

    The advent of colorectal cancer (CRC) screening, notably colonoscopy, has reduced deaths from this common and deadly malignancy by 30 percent. Unfortunately, colonoscopy misses about 24 percent of small and flat polyps, which often develop into aggressive forms of CRC. Now Wellington Pham, Ph.D., and colleagues report that a novel fluorescent nanobeacon can discern normal […]

    Annual Meharry-Vanderbilt-TSU Cancer Partnership retreat April 8

    Friday, March 24th, 2017

    The Meharry Medical College, Vanderbilt-Ingram Cancer Center (VICC) and Tennessee State University (TSU) Cancer Partnership will host its 16th Annual Cancer Retreat on Saturday, April 8, from 8:30 a.m. to 2:30 p.m. The retreat will be held on the Meharry Medical College campus in the Harold D. West Basic Sciences Building, Room M001. This year’s […]

    Study takes 3-D perspective on colorectal cancer

    Friday, March 24th, 2017

    Despite dramatic recent advances in treatment, colorectal cancer killed more than 49,000 Americans last year, according to the National Cancer Institute, making it the second most lethal malignancy after cancers of the lung and bronchus. Determined to reduce the death toll, researchers at Vanderbilt University Medical Center recently put on their 3-D “glasses” and took […]

    Breast cancer program lands new research grants

    Friday, March 24th, 2017

    Several investigators in Vanderbilt-Ingram Cancer Center’s (VICC) Breast Cancer Program have received grant awards to support translational research that may improve disease outcomes for patients. The grants totaling more than $3 million will fund mechanistic science and clinical trials designed to test novel therapy combinations and determine why some forms of breast cancer become resistant […]

    Active surveillance preserves quality of life for prostate cancer patients

    Tuesday, March 21st, 2017

    Faced with the negative quality-of-life effects from surgery and radiation treatments for prostate cancer, low risk patients may instead want to consider active surveillance with their physician, according to a study released Tuesday by the Journal of the American Medical Association (JAMA). The Vanderbilt University Medical Center study led by Daniel Barocas, M.D., MPH, associate […]

    New target for colorectal cancer

    Monday, March 20th, 2017

    In a new study published in the journal Oncogene, Dana Hardbower, Ph.D., Keith Wilson, M.D., and colleagues demonstrated that epidermal growth factor receptor (EGFR) signaling in macrophages is associated with increased colitis-associated colon cancer development. While inflammatory bowel disease and colitis can increase risk of colon cancer, the mechanisms behind this connection are poorly understood. […]

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