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    News: Cancer Research

    Links between immune cells and metabolism explored

    Thursday, November 10th, 2016

    At the intersection of immunology and metabolism is a burgeoning new field: immunometabolism. It’s an area where Vanderbilt has exceptional strengths, said Jeffrey Rathmell, Ph.D., Cornelius Vanderbilt Professor of Immunobiology. “It’s an unsung area of expertise here,” said Rathmell, who is also professor of Pathology, Microbiology and Immunology and professor of Cancer Biology. “There are […]

    Study details rare heart risk of certain cancer therapies

    Monday, November 7th, 2016

    Combination therapy using two approved immunotherapy drugs for cancer treatment may cause rare and sometimes fatal cardiac side effects linked to an unexpected immune response. In a study led by Vanderbilt University Medical Center (VUMC) investigators and published in the Nov. 3 issue of the New England Journal of Medicine, researchers describe two cases of […]

    A DARPP role in gastric cancer

    Monday, November 7th, 2016

    Infection with Helicobacter pylori bacterium affects almost half of the world’s population. Chronic infection with H. pylori and its associated inflammation are considered the main risk factors for the development of gastric cancer, the third leading cause of cancer-related deaths worldwide. Previously, Wael El-Rifai, M.D., Ph.D., and colleagues had discovered that DARPP-32 protein, overexpressed in […]

    DNA damage response protein

    Monday, October 31st, 2016

    Researchers at Vanderbilt University and Vanderbilt University Medical Center have determined that a previously uncharacterized protein called ETAA1 is a “replication stress response protein” with an essential role in maintaining the integrity of the genome. The finding by Thomas Bass, David Cortez, Ph.D., and colleagues, reported Oct. 10 in Nature Cell Biology, adds to the list […]

    Single-cell study of tumor samples

    Monday, October 31st, 2016

    The presence of various cell types in tumors – cellular heterogeneity – makes treatment challenging, since a therapy may kill one cell type but not affect another. Studying heterogeneous cell populations requires single-cell analysis. Ken Lau, Ph.D., and colleagues previously described a method for preparing single-cell suspensions from epithelial tissues – the type of tissue […]

    Emerging field of cardio-oncology seeks better tools

    Monday, October 31st, 2016

    Improved therapies have led to a spike in the number of people living with cancer, and today there are more than 15.5 million survivors in the United States. However, some of these therapies can cause toxicities to the heart, the vessels and the body’s metabolism. In a new article in the The New England Journal […]

    Cancer disparities grant with Meharry, TSU gains renewal

    Thursday, October 20th, 2016

    A multi-year collaborative cancer research effort among Vanderbilt University Medical Center (VUMC), Meharry Medical College (MMC) and Tennessee State University (TSU) will receive continued federal funding through the renewal of U54 Partners in Eliminating Cancer Disparities Grants from the National Cancer Institute (NCI), a division of the National Institutes of Health. This is the 17th […]

    EGF receptor found to regulate macrophage inflammation in gut

    Thursday, October 13th, 2016

    Researchers at Vanderbilt University School of Medicine have uncovered a link between epidermal growth factor receptor (EGFR) signaling and the inflammatory response to bacterial infection in the gastrointestinal tract. In particular, they have found — in mice and human tissue — that EGFR signaling regulates the response of an inflammatory macrophage (a type of white […]

    Vanderbilt scientists to lead chronic disease research initiative in Vietnam

    Thursday, October 6th, 2016

    Scientists in the Vanderbilt Epidemiology Center (VEC) and Vanderbilt-Ingram Cancer Center (VICC) have been awarded a grant to plan and develop a Regional Center of Research Excellence in non-communicable diseases in Vietnam. Xiao Ou Shu, M.D., Ph.D., MPH, associate director for Global Health and co-leader of the Cancer Epidemiology Research Program at VICC, and Thuan […]

    VA honors Richmond’s scientific contributions

    Thursday, October 6th, 2016

    Vanderbilt University cancer researcher Ann Richmond, Ph.D., has won the 2016 William S. Middleton Award, the highest honor for scientific achievement bestowed by the Biomedical Laboratory Research and Development Service of the U.S. Department of Veterans Affairs (VA). Richmond is Ingram Professor of Cancer Research and professor of Cancer Biology and Medicine at Vanderbilt University […]

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