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    News: Cancer Research

    Single-cell analysis of solid tumors

    Wednesday, December 14th, 2016

    Vanderbilt researchers have pioneered a single-cell technique for solid tumors that have been challenging to characterize because they contain many cell types connected in a matrix. Mass cytometry detects proteins and signaling events in cells using antibodies tagged with metal reporters and a specialized mass spectrometer. Detecting 35 proteins and revealing signals in rare “1 […]

    Study links lifestyle factors to formation of high-risk polyps

    Thursday, December 8th, 2016

    Lifestyle factors like cigarette smoking and red meat consumption are known to be associated with an increased risk of colon polyps that can lead to colorectal cancer. Polyps are small growths on the lining of the colon, and while some polyps are harmless others can progress to cancer. A new study led by Vanderbilt University […]

    Award spurs Jonna’s research on ocular melanoma

    Thursday, December 8th, 2016

    Gowtham Jonna, M.D., senior retina fellow at the Vanderbilt Eye Institute, recently received a VitreoRetinal Surgery Foundation (VRSF) Research Award. Gowtham Jonna, M.D. The purpose of the award is to support young investigators conducting research on macular and retinal disease and to encourage a career devoted to retinal disease and research. Jonna is working on […]

    Targeting the “un-targetable”

    Thursday, December 1st, 2016

    Triple negative breast cancers (TNBC) are so named because they lack common genetic “target” mutations that can be easily treated with specific cancer drugs. However, in a recent study published in Molecular Cancer Therapeutics, Deborah Lannigan, Ph.D., and colleagues investigated a new target involved in TNBC called RSK. They demonstrated that RSK can help cancers […]

    Graduate student’s cancer studies land NCI support

    Thursday, November 17th, 2016

    Kamakoti “Kami” Bhat, a fifth-year graduate student in the lab of David Cortez, Ph.D., professor of Biochemistry in the School of Medicine, has achieved a “first” for Vanderbilt University. She is the first Vanderbilt graduate student to win an “F99/K00” predoctoral-to-postdoctoral fellow transition award from the National Cancer Institute (NCI). The grant program is designed […]

    V Foundation grants bolster cancer initiatives

    Thursday, November 17th, 2016

    Two Vanderbilt-Ingram Cancer Center (VICC) investigators have earned grant awards from The V Foundation for Cancer Research, continuing the foundation’s support for innovative cancer research initiatives at VICC. Raymond Blind, Ph.D., assistant professor of Medicine, Biochemistry and Pharmacology, has received a two-year V Foundation grant to examine how proteins induce cancerous tumors to grow. Blind’s […]

    Links between immune cells and metabolism explored

    Thursday, November 10th, 2016

    At the intersection of immunology and metabolism is a burgeoning new field: immunometabolism. It’s an area where Vanderbilt has exceptional strengths, said Jeffrey Rathmell, Ph.D., Cornelius Vanderbilt Professor of Immunobiology. “It’s an unsung area of expertise here,” said Rathmell, who is also professor of Pathology, Microbiology and Immunology and professor of Cancer Biology. “There are […]

    Study details rare heart risk of certain cancer therapies

    Monday, November 7th, 2016

    Combination therapy using two approved immunotherapy drugs for cancer treatment may cause rare and sometimes fatal cardiac side effects linked to an unexpected immune response. In a study led by Vanderbilt University Medical Center (VUMC) investigators and published in the Nov. 3 issue of the New England Journal of Medicine, researchers describe two cases of […]

    A DARPP role in gastric cancer

    Monday, November 7th, 2016

    Infection with Helicobacter pylori bacterium affects almost half of the world’s population. Chronic infection with H. pylori and its associated inflammation are considered the main risk factors for the development of gastric cancer, the third leading cause of cancer-related deaths worldwide. Previously, Wael El-Rifai, M.D., Ph.D., and colleagues had discovered that DARPP-32 protein, overexpressed in […]

    DNA damage response protein

    Monday, October 31st, 2016

    Researchers at Vanderbilt University and Vanderbilt University Medical Center have determined that a previously uncharacterized protein called ETAA1 is a “replication stress response protein” with an essential role in maintaining the integrity of the genome. The finding by Thomas Bass, David Cortez, Ph.D., and colleagues, reported Oct. 10 in Nature Cell Biology, adds to the list […]

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