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    News: Cancer Research

    Ayers Institute spurred key cancer research gains

    Friday, November 13th, 2015

    In 2005, Tennessee philanthropists Jim and Janet Ayers gave $10 million to help Vanderbilt University scientists find early markers for colorectal cancer that could improve diagnosis and potentially save lives. Within nine years, the gift, which established the Jim Ayers Institute for Precancer Detection and Diagnosis at the Vanderbilt-Ingram Cancer Center (VICC), had yielded an […]

    Study helps clarify components of DNA ‘copy machine’

    Friday, November 13th, 2015

    Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. They were surprised to identify new proteins among the many that participate in copying DNA. “Imagine that; we’ve been studying DNA replication for 50 years, and we’re still finding new proteins that are required for replication,” […]

    Computer extracts cancer stage

    Friday, November 13th, 2015

    Cancer stage, an important element in prognosis, is often documented in narrative form in medical records, which leads to time-consuming abstraction by tumor registry personnel and other secondary users of these records. Jeremy Warner, M.D., M.S., and colleagues developed a computerized natural language processing algorithm to extract cancer stages from electronic medical records. Records from […]

    Investigators find clues to melanoma treatment resistance

    Friday, October 30th, 2015

    Nearly half of all patients with malignant melanoma, the most deadly form of skin cancer, have a mutation in the BRAF gene found in their tumors. Mutations in the BRAF gene turn on a cancer growth switch known as the MAP kinase pathway. In recent years, new drugs have been approved that target the BRAF/MAPK […]

    VUMC and Incyte Corp. form new scientific alliance

    Thursday, October 22nd, 2015

    Vanderbilt University Medical Center (VUMC) investigators have joined forces with scientists at Incyte Corp. to explore new therapies for the treatment of various types of cancer, as well as other diseases. The company has agreed to help fund basic and translational science research by VUMC investigators. Incyte Corp. is a Wilmington, Delaware-based biopharmaceutical company focused […]

    Biomarker for intestinal tumors

    Thursday, October 22nd, 2015

    The incidence of pancreatic and small intestinal neuroendocrine tumors (NETs) has risen over the past decade. NETs are the second most common cancers in the small intestine and pancreas and are frequently associated with liver metastasis. Safia Salaria, M.D., and colleagues examined expression of CD24 – a biomarker for normal and cancer stem cells – […]

    New faculty: Bethany Rhoten examines quality of life among cancer survivors

    Monday, October 19th, 2015

    Bethany Rhoten’s research focuses on issues that few people openly discuss—those surrounding body image and sexuality among cancer survivors. “While conducting research for my dissertation, I saw how difficult it is when a patient with head and neck cancer looks in the mirror and the person they see is not the person they saw six […]

    Study shows compression device helps ease lymphedema

    Friday, October 9th, 2015

    Lymphedema patients saw a nearly 80 percent reduction in cellulitis episodes by using an advanced pneumatic compression device at home, according to a study in JAMA Dermatology co-authored by Vanderbilt University School of Nursing’s Sheila Ridner, Ph.D., and University of Minnesota School of Public Health Associate Professor Pinar Karaca-Mandic, Ph.D. The reduction in episodes also led […]

    Potential target for lung cancer therapy

    Friday, October 9th, 2015

    A protein that transports the amino acid glutamine is a potential biomarker and therapeutic target for non-small cell lung cancer, Vanderbilt researchers reported in the Oct. 1 International Journal of Cancer. Pierre Massion, M.D., and colleagues previously demonstrated that the protein SLC1A5 is the primary transporter of glutamine – a modulator of cell growth and oxidative […]

    Komen, VICC partnership bolsters breast cancer research

    Friday, October 9th, 2015

    For more than twenty years, Vanderbilt-Ingram Cancer Center’s (VICC) primary source of outside funding has been provided by the National Institutes of Health. But in breast cancer, Susan G. Komen, a nonprofit dedicated to breast cancer research and community services, has been a significant sponsor of research and patient care support. Komen has provided more […]

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