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News: Colorectal Cancer

Study identifies novel genetic factors for colorectal cancer risk

Wednesday, January 16th, 2019

Studying cellular deliveries

Friday, October 26th, 2018

In an article recently published in Cell Reports, James G. Patton, PhD, and colleagues studied how colon cancer cells can secrete long RNAs in carefully regulated ways.

Cancer Moonshot award to help map tumor progression

Thursday, September 27th, 2018

A trans-institutional team of researchers at Vanderbilt University Medical Center and Vanderbilt University has received an $11 million Cancer Moonshot grant to build a single-cell resolution atlas to map out the routes that benign colonic polyps take to progress to colorectal cancer.

SMAD4 clue to colon cancer

Friday, July 6th, 2018

A recent study has linked inflammation-driven carcinogenesis in the colon to loss of an important signaling protein called SMAD4.

Calcium intake and colorectal cancer

Friday, October 20th, 2017

Calcium plays key roles in cellular signaling, proliferation and death. Previous studies exploring the relationship between dietary calcium intake and colorectal cancer have had contradictory results, perhaps due to no consideration of variation in calcium reabsorption by the kidney.

Researchers find novel mechanism of resistance to anti-cancer drugs

Friday, October 20th, 2017

The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States. However, many patients have tumors with genetic mutations that make them resistant to these anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, or the cancers develop resistance during treatment.

Fatty acids and adenoma risk

Monday, August 28th, 2017

Dietary intake of polyunsaturated fatty acids (PUFAs) has been associated with risk of colorectal cancer, with omega-6 PUFAs increasing and omega-3 PUFAs decreasing risk. Most studies, however, have relied on questionnaires to assess consumption of fatty acids, and results have been inconsistent. Harvey Murff, M.D., and colleagues have studied a blood-based biomarker of PUFA intake. […]

Coffey lands major NCI award to support colorectal cancer research

Friday, June 9th, 2017

Vanderbilt’s Robert Coffey Jr., M.D., has received an Outstanding Investigator Award from the National Cancer Institute (NCI) — more than $6.6 million over seven years — to support studies aimed at advancing the diagnosis and treatment of colorectal cancer (CRC), a leading cancer killer. Robert Coffey Jr., M.D. Coffey, Ingram Professor of Cancer Research and […]

Glowing receptors help find and track cancerous growth

Friday, May 19th, 2017

Under the microscope, they sparkle like emeralds, these molecules that may hold a key to understanding — and stopping — cancerous growth. The molecules are protein receptors that bind epidermal growth factor (EGF). Overexpression of the EGF receptor has been linked to multiple types of cancer. Drugs that block the receptor have become routine treatment […]

Nanobeacon lights up colon tumors

Sunday, April 2nd, 2017

The advent of colorectal cancer (CRC) screening, notably colonoscopy, has reduced deaths from this common and deadly malignancy by 30 percent. Unfortunately, colonoscopy misses about 24 percent of small and flat polyps, which often develop into aggressive forms of CRC. Now Wellington Pham, Ph.D., and colleagues report that a novel fluorescent nanobeacon can discern normal […]

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