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News: Colorectal Cancer

New guidelines recommend colonoscopy at 45

Thursday, April 25th, 2019

The American Cancer Society now recommends people at average risk be screened for colorectal cancer via colonoscopy, or another method, starting at age 45, rather than at age 50.

Lighting up colorectal cancer

Monday, March 4th, 2019

Wellington Pham, PhD, and colleagues in Japan, have developed a nanobeacon imaging agent to aid the early detection of colorectal cancer during colonoscopy.

Major grant to bolster research on inflammation-related cancers

Thursday, January 24th, 2019

Cancer Research UK has awarded a 20-million-pound grant (about $26 million U.S.) to a team of international investigators, including Vanderbilt’s James Goldenring, MD, PhD, to study inflammation-related cancers.

Study identifies novel genetic factors for colorectal cancer risk

Wednesday, January 16th, 2019

A large-scale study conducted among East Asians and led by Vanderbilt researchers has identified multiple, previously unknown genetic risk factors for colorectal cancer.

Studying cellular deliveries

Friday, October 26th, 2018

In an article recently published in Cell Reports, James G. Patton, PhD, and colleagues studied how colon cancer cells can secrete long RNAs in carefully regulated ways.

Cancer Moonshot award to help map tumor progression

Thursday, September 27th, 2018

A trans-institutional team of researchers at Vanderbilt University Medical Center and Vanderbilt University has received an $11 million Cancer Moonshot grant to build a single-cell resolution atlas to map out the routes that benign colonic polyps take to progress to colorectal cancer.

SMAD4 clue to colon cancer

Friday, July 6th, 2018

A recent study has linked inflammation-driven carcinogenesis in the colon to loss of an important signaling protein called SMAD4.

Calcium intake and colorectal cancer

Friday, October 20th, 2017

Calcium plays key roles in cellular signaling, proliferation and death. Previous studies exploring the relationship between dietary calcium intake and colorectal cancer have had contradictory results, perhaps due to no consideration of variation in calcium reabsorption by the kidney.

Researchers find novel mechanism of resistance to anti-cancer drugs

Friday, October 20th, 2017

The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States. However, many patients have tumors with genetic mutations that make them resistant to these anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, or the cancers develop resistance during treatment.

Fatty acids and adenoma risk

Monday, August 28th, 2017

Dietary intake of polyunsaturated fatty acids (PUFAs) has been associated with risk of colorectal cancer, with omega-6 PUFAs increasing and omega-3 PUFAs decreasing risk. Most studies, however, have relied on questionnaires to assess consumption of fatty acids, and results have been inconsistent. Harvey Murff, M.D., and colleagues have studied a blood-based biomarker of PUFA intake. […]

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