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News: Colorectal Cancer

Calcium intake and colorectal cancer

Friday, October 20th, 2017

Calcium plays key roles in cellular signaling, proliferation and death. Previous studies exploring the relationship between dietary calcium intake and colorectal cancer have had contradictory results, perhaps due to no consideration of variation in calcium reabsorption by the kidney.

Researchers find novel mechanism of resistance to anti-cancer drugs

Friday, October 20th, 2017

The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States. However, many patients have tumors with genetic mutations that make them resistant to these anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, or the cancers develop resistance during treatment.

Fatty acids and adenoma risk

Monday, August 28th, 2017

Dietary intake of polyunsaturated fatty acids (PUFAs) has been associated with risk of colorectal cancer, with omega-6 PUFAs increasing and omega-3 PUFAs decreasing risk. Most studies, however, have relied on questionnaires to assess consumption of fatty acids, and results have been inconsistent. Harvey Murff, M.D., and colleagues have studied a blood-based biomarker of PUFA intake. […]

Coffey lands major NCI award to support colorectal cancer research

Friday, June 9th, 2017

Vanderbilt’s Robert Coffey Jr., M.D., has received an Outstanding Investigator Award from the National Cancer Institute (NCI) — more than $6.6 million over seven years — to support studies aimed at advancing the diagnosis and treatment of colorectal cancer (CRC), a leading cancer killer. Robert Coffey Jr., M.D. Coffey, Ingram Professor of Cancer Research and […]

Glowing receptors help find and track cancerous growth

Friday, May 19th, 2017

Under the microscope, they sparkle like emeralds, these molecules that may hold a key to understanding — and stopping — cancerous growth. The molecules are protein receptors that bind epidermal growth factor (EGF). Overexpression of the EGF receptor has been linked to multiple types of cancer. Drugs that block the receptor have become routine treatment […]

Nanobeacon lights up colon tumors

Sunday, April 2nd, 2017

The advent of colorectal cancer (CRC) screening, notably colonoscopy, has reduced deaths from this common and deadly malignancy by 30 percent. Unfortunately, colonoscopy misses about 24 percent of small and flat polyps, which often develop into aggressive forms of CRC. Now Wellington Pham, Ph.D., and colleagues report that a novel fluorescent nanobeacon can discern normal […]

Study takes 3-D perspective on colorectal cancer

Friday, March 24th, 2017

Despite dramatic recent advances in treatment, colorectal cancer killed more than 49,000 Americans last year, according to the National Cancer Institute, making it the second most lethal malignancy after cancers of the lung and bronchus. Determined to reduce the death toll, researchers at Vanderbilt University Medical Center recently put on their 3-D “glasses” and took […]

New target for colorectal cancer

Monday, March 20th, 2017

In a new study published in the journal Oncogene, Dana Hardbower, Ph.D., Keith Wilson, M.D., and colleagues demonstrated that epidermal growth factor receptor (EGFR) signaling in macrophages is associated with increased colitis-associated colon cancer development. While inflammatory bowel disease and colitis can increase risk of colon cancer, the mechanisms behind this connection are poorly understood. […]

Geiger’s focus on the small details serves patients well

Thursday, February 16th, 2017

Neat stacks of paper are lined up on the desk of Timothy Geiger, M.D., with each stack representing a challenge. For example, one sheet has a flow chart sketched on it — Geiger’s musing on ways to more efficiently use Vanderbilt University Medical Center’s (VUMC) operating rooms, matching the best locations with case types and […]

Colorectal cancer clues

Thursday, January 26th, 2017

The colorectum (large intestine) is divided into proximal and distal regions based on differences in embryonic origin, physiological functions and gene expression. Colorectal cancer is heterogeneous depending on its location: for example, proximal tumors have a higher mortality than distal tumors. It is not known, however, whether molecular events contribute to the differences in cancers […]

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