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    News: Colorectal Cancer

    Tools for exploring ‘omics’ data

    Thursday, May 21st, 2015

    Advances in technology have generated vast amounts of “omics” data: genomic, epigenomic, transcriptomic, proteomic and metabolomic changes for all types of specimens. Bridging the gap between data generation and investigators’ ability to retrieve and interpret data is essential to realize the biological and clinical value of this wealth of information. Bing Zhang, Ph.D., and colleagues […]

    American Surgical Association lauds VUMC’s Beauchamp

    Thursday, May 14th, 2015

    R. Daniel Beauchamp, M.D., chair of the Section of Surgical Sciences and the John Clinton Foshee Distinguished Professor of Surgery, was selected to receive the 2015 Flance-Karl Award from the American Surgical Association (ASA). Beauchamp, who is also a professor of Surgery, Cancer Biology and Cell and Developmental Biology, traveled to San Diego last week […]

    Kachnic to join VUMC as new chair of Radiation Oncology

    Thursday, May 7th, 2015

    Lisa Kachnic, M.D., professor and chair of Radiation Oncology and associate director of Multidisciplinary Cancer Research at Boston University School of Medicine (BUSM), and chief of Radiation Oncology at Boston Medical Center (BMC), has been named the new professor and chair of the Vanderbilt Department of Radiation Oncology. She will join the faculty on Sept. […]

    Best hospital depends on cancer type

    Thursday, April 23rd, 2015

    The idea of a “Best Hospital for Cancer” does not reflect the fact that cancer comprises many different diseases. Jeffery Goldstein, M.D., Ph.D., a resident in the Department of Pathology, Microbiology and Immunology at Vanderbilt, and Vinay Prasad, M.D., MPH, aimed to rank the 50 highest ranked cancer hospitals – from the 2013 U.S. News […]

    NCI report shows U.S. cancer deaths on decline

    Thursday, April 2nd, 2015

    The death rates for most forms of cancer continue to decline at a modest pace among men, women and children in the United States, according to the Annual Report to the Nation on the Status of Cancer 1975 – 2011. The report from the National Cancer Institute, a division of the National Institutes of Health, […]

    Gene profile predicts metastasis

    Thursday, February 12th, 2015

    Gene expression profiling has been applied to predict metastatic recurrence, the leading cause of deaths in patients with colorectal carcinoma. However, the biological mechanism is not completely understood, driving poor clinical outcomes. To address this issue, Dan Beauchamp, M.D., Bing Zhang, Ph.D., and colleagues analyzed the 11 human microarray datasets from 1,295 tumor specimens as […]

    Protein “pockets” help ID cancer genes

    Tuesday, November 11th, 2014

    Somatic mutations, which can occur in any cell except sperm or egg, are not inheritable. Several recent studies have demonstrated that disease-causing mutations commonly alter protein folding, protein stability and protein-protein interactions. It has been difficult, however, to determine which somatic mutations identified in tumor samples “drive” the cancer development and which are just “along […]

    Study identifies genes tied to colon cancer

    Friday, August 22nd, 2014

    by Dagny Stuart Colorectal cancer is one of the leading causes of death among populations around the world. While diet, physical activity and other lifestyle factors can influence the risk of developing the disease, hereditary factors also play an important role. Genetic factors identified to date explain only a small fraction of colorectal cancer (CRC), […]

    Colon cancer’s protein signatures identified

    Friday, July 25th, 2014

    by Bill Snyder A Vanderbilt University-led research team has identified protein “signatures” of genetic mutations that drive colorectal cancer, the nation’s second leading cause of cancer deaths after lung cancer. The technological tour de force, described as the first integrated “proteogenomic” characterization of human cancer, was reported online this week by the journal Nature. It […]

    NIH Grant Supports Colon Research

    Friday, August 16th, 2013

    Robert Coffey Jr., M.D., Ingram Professor of Cancer Research at Vanderbilt University, has received a five-year, $5.2 million grant from the National Institutes of Health (NIH) to study the role of extracellular RNA (ex-RNA) in colorectal cancer. Most RNA works inside cells to translate genes into proteins that are necessary for organisms to function. Now, recent […]

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