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    News: Gastrointestinal Cancer

    VUMC to Study Potential Approach to Reverse Precancerous Stomach Lesions

    Thursday, April 27th, 2017

    Vanderbilt University Medical Center (VUMC) cancer researcher James Goldenring, M.D., Ph.D., has received a two-year, $200,000 grant from the DeGregorio Family Foundation in Pleasantville, New York, to begin clinical trials of a potential approach for reversing precancerous stomach lesions. Stomach cancer is the fourth leading cause of cancer-related deaths worldwide after lung, liver and colorectal […]

    Study takes 3-D perspective on colorectal cancer

    Friday, March 24th, 2017

    Despite dramatic recent advances in treatment, colorectal cancer killed more than 49,000 Americans last year, according to the National Cancer Institute, making it the second most lethal malignancy after cancers of the lung and bronchus. Determined to reduce the death toll, researchers at Vanderbilt University Medical Center recently put on their 3-D “glasses” and took […]

    Improving therapies for GI tumors

    Thursday, February 23rd, 2017

    The signaling protein Aurora kinase A (AURKA) is overexpressed in several cancer types and has diverse oncogenic functions, making it an attractive druggable cancer target. Wael El-Rifai, M.D., Ph.D., and colleagues are exploring a role for AURKA in upper gastrointestinal cancers, which are characterized by poor patient survival and resistance to chemotherapy. Using in vitro […]

    New target for chronic infection

    Thursday, February 2nd, 2017

    The greatest risk factor for gastric cancer is chronic infection by the bacterium, Helicobacter pylori. In a study in mice published by the Proceedings of the National Academy of Sciences, Dana Hardbower, Keith Wilson, M.D., and colleagues found that macrophage activation has a critical role in regulating H. pylori colonization and gastric inflammation. Macrophages are […]

    Metastatic pancreatic cancer ‘reprograms’ for malignancy

    Thursday, January 19th, 2017

    Metastatic pancreatic cancer — cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths — changes its metabolism and is “reprogrammed” for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics. It may be possible to reverse the malignant reprogramming to treat metastatic pancreatic cancer, […]

    Midgut neuroendocrine tumor prognosis

    Thursday, January 12th, 2017

    Patients with small intestine neuroendocrine tumors often have mesenteric tumor deposits (MTDs) in the abdomen – discrete tumor nodules that are not connected to the primary tumor. The clinical significance of these tumor deposits has not been thoroughly investigated, and they are not included in the American Joint Committee on Cancer (AJCC) staging system for […]

    Study links lifestyle factors to formation of high-risk polyps

    Thursday, December 8th, 2016

    Lifestyle factors like cigarette smoking and red meat consumption are known to be associated with an increased risk of colon polyps that can lead to colorectal cancer. Polyps are small growths on the lining of the colon, and while some polyps are harmless others can progress to cancer. A new study led by Vanderbilt University […]

    EGF receptor found to regulate macrophage inflammation in gut

    Thursday, October 13th, 2016

    Researchers at Vanderbilt University School of Medicine have uncovered a link between epidermal growth factor receptor (EGFR) signaling and the inflammatory response to bacterial infection in the gastrointestinal tract. In particular, they have found — in mice and human tissue — that EGFR signaling regulates the response of an inflammatory macrophage (a type of white […]

    Colon cancer awareness event set for Aug. 5

    Thursday, July 28th, 2016

    For some people cancer, especially colon cancer, is a persistent and potentially deadly visitor affecting family members from one generation to the next. Individuals who have a parent, sibling or child diagnosed with colon cancer have double the risk of developing the disease. But not all colon cancer is caused by hereditary factors. Vanderbilt-Ingram Cancer […]

    Idrees receives award for cancer outcomes research

    Thursday, July 7th, 2016

    Kamran Idrees, M.D., MSCI, assistant professor of Surgery, has received a Young Investigator Award from the Society of Surgical Oncology Foundation (SSO). The award supports innovative concepts designed to improve health outcomes through advances in the delivery of care. Idrees, who joined the Vanderbilt faculty in 2012, said the one-year award “was an unexpected honor […]

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