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News: GI SPORE

SMAD4 clue to colon cancer

Friday, July 6th, 2018

A recent study has linked inflammation-driven carcinogenesis in the colon to loss of an important signaling protein called SMAD4.

A spicy finding

Thursday, January 18th, 2018

Extracts of the plant turmeric — the spice that gives Indian curries a yellow color — have been used as an anti-inflammatory treatment in traditional Asian medicine for centuries. Claus Schneider, PhD, and colleagues have discovered that curcumin (the active chemical compound in turmeric) is a “pro-drug” that is converted into reactive metabolites with anti-inflammatory activities.

Researchers find novel mechanism of resistance to anti-cancer drugs

Friday, October 20th, 2017

The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States. However, many patients have tumors with genetic mutations that make them resistant to these anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, or the cancers develop resistance during treatment.

Coffey lands major NCI award to support colorectal cancer research

Friday, June 9th, 2017

Vanderbilt’s Robert Coffey Jr., M.D., has received an Outstanding Investigator Award from the National Cancer Institute (NCI) — more than $6.6 million over seven years — to support studies aimed at advancing the diagnosis and treatment of colorectal cancer (CRC), a leading cancer killer. Robert Coffey Jr., M.D. Coffey, Ingram Professor of Cancer Research and […]

Study takes 3-D perspective on colorectal cancer

Friday, March 24th, 2017

Despite dramatic recent advances in treatment, colorectal cancer killed more than 49,000 Americans last year, according to the National Cancer Institute, making it the second most lethal malignancy after cancers of the lung and bronchus. Determined to reduce the death toll, researchers at Vanderbilt University Medical Center recently put on their 3-D “glasses” and took […]

Metastatic pancreatic cancer ‘reprograms’ for malignancy

Thursday, January 19th, 2017

Metastatic pancreatic cancer — cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths — changes its metabolism and is “reprogrammed” for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics. It may be possible to reverse the malignant reprogramming to treat metastatic pancreatic cancer, […]

Midgut neuroendocrine tumor prognosis

Thursday, January 12th, 2017

Patients with small intestine neuroendocrine tumors often have mesenteric tumor deposits (MTDs) in the abdomen – discrete tumor nodules that are not connected to the primary tumor. The clinical significance of these tumor deposits has not been thoroughly investigated, and they are not included in the American Joint Committee on Cancer (AJCC) staging system for […]

Singer’s concert honors care received at Cancer Center

Thursday, March 24th, 2016

A cancer patient’s gratitude toward his Vanderbilt-Ingram Cancer Center (VICC) physician led to a star-studded concert to benefit the Cancer Center. Colon cancer survivor and country artist Wade Hayes was joined by six-time CMA and ACM Female Vocalist of the Year Miranda Lambert, four-time Grammy and CMA Award-winning artist Steve Wariner and Kix Brooks, CMA […]