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News: Genome Maintenance Research Program

International Association of Medical Science Educators honors Osheroff

Thursday, July 11th, 2019

Neil Osheroff, PhD, received the Distinguished Career Award for Excellence in Teaching and Educational Scholarship from the International Association of Medical Science Educators (IAMSE).

Potential probe for early ovarian cancer

Saturday, June 29th, 2019

Larry Marnett and colleagues have developed what may become the first agent for targeted PET imaging of cancer tissues, such as ovarian cancer, that express high levels of the COX-1 enzyme.

Steroid binding to metabolic enzyme

Saturday, June 29th, 2019

Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer.

Researchers putting the brakes on lethal childhood cancer

Friday, May 3rd, 2019

A recent study suggests that blocking the MYC protein could be “unexpectedly effective” in treating malignant rhabdoid tumor (MRT) is one of the most aggressive and lethal childhood cancers.

Correctly copying DNA

Friday, March 15th, 2019

A precise understanding of how the enzyme topoisomerase II cuts DNA could lead to better anti-cancer therapies.

Achilles’ heel for kidney cancer

Monday, March 4th, 2019

A recent study found that renal cell carcinoma cells with mutations in an enzyme-encoding gene, SETD2, were sensitive to a drug that inhibits the enzyme PI3K-beta.

Novel DNA repair mechanism preserves genome integrity: study

Monday, March 4th, 2019

Vanderbilt investigators have discovered a new DNA repair pathway that guards against genomic mutations. Their findings were published recently in the journal Cell.

The yin and yang of cell signaling

Thursday, February 14th, 2019

Changes in enzymes involved in lysophospholipid signaling can activate a pathway implicated in development of cancer, a recent study suggests.

Cell death pathway implicated in bone marrow failure

Monday, February 4th, 2019

Vanderbilt researchers have linked a specific form of programmed cell death to myelodysplastic syndrome, a type of bone marrow failure.

DNA’s on/off switch

Friday, January 18th, 2019

A recent study shows that a component of the DNA primase enzyme acts as a reversible on/off switch for DNA binding and represents a fundamentally new method of communication between DNA-processing enzymes.

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