A recent study showing that protein called RADX helps regulate the process of DNA repair may help us better understand why some cancers are more or less resistant to certain therapies
News: Genome Maintenance Research Program
Kimryn Rathmell, MD, PhD, Cornelius Abernathy Craig Professor of Medicine and director of the Division of Hematology and Oncology at Vanderbilt-Ingram Cancer Center (VICC), has received a grant to research the role of immunosuppression in the tumor microenvironment for kidney cancer.
A new study by W. Kimryn Rathmell, MD, PhD, and colleagues, reveals a gene mutation’s role in Von Hippel-Lindau syndrome, a genetically inherited disease which causes tumor growth in several organs.
W. Kimryn Rathmell, MD, PhD, Cornelius A. Craig Professor of Medicine and director of the Division of Hematology and Oncology at Vanderbilt University Medical Center (VUMC), has been elected to the nominating committee of the American Society of Clinical Oncology (ASCO).
The first line of defense against skin cancer is the ability to repair DNA damage caused by UV light. Walter J. Chazin, PhD, and colleagues investigated how XPA – a protein involved in the repair of certain DNA damage – interacts with DNA and the effects of several disease-associated mutations in XPA on its molecular structure and ability to bind DNA.
Radiation-induced pulmonary fibrosis — tissue scarring that can permanently impair lung function — limits the delivery of therapeutic radiation doses to non-small cell lung cancer. To develop strategies for preventing or reducing fibrosis, Michael Freeman, Ph.D., and colleagues are exploring the cell types and factors that contribute to the radiation-induced fibrotic response.
Histone deacetylases (HDACs) are enzymes that modulate gene expression and have important roles in development and disease. HDAC inhibitors are active against lymphoma, and understanding the roles of specific HDACs is important for further therapeutic development. Scott Hiebert, Ph.D., and colleagues used a mouse model to explore the role of HDAC3 in the early development […]
Researchers at Vanderbilt University Medical Center (VUMC) have discovered a protein that may lead to a new way to prevent resistance and improve outcomes for patients whose cancers have mutations in the tumor suppressor gene BRCA2. The protein, RADX, is a DNA-binding protein. It regulates the activity of an enzyme called RAD51, which helps repair tumor-promoting […]
Damage to DNA can stall the machinery that faithfully replicates DNA from cell to cell. Failed DNA replication can have health consequences such as cancer. An ancient primase polymerase – PrimPol – helps the replication machinery skip over common lesions and restarts DNA synthesis by “repriming” further away from roadblocks. Now in a study published […]
W. Kimryn Rathmell, M.D., Ph.D., director of the Division of Hematology/Oncology at Vanderbilt University Medical Center (VUMC), has been named vice president of The American Society for Clinical Investigation (ASCI). W. Kimryn Rathmell, M.D., Ph.D. Rathmell, who is the Cornelius Abernathy Craig Professor of Medicine, will serve a four-year term, initially as vice president, then […]