Skip to Content
 

News: Genome Maintenance Research Program

Steroid binding to metabolic enzyme

Saturday, June 29th, 2019

Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer.

Researchers putting the brakes on lethal childhood cancer

Friday, May 3rd, 2019

A recent study suggests that blocking the MYC protein could be “unexpectedly effective” in treating malignant rhabdoid tumor (MRT) is one of the most aggressive and lethal childhood cancers.

Correctly copying DNA

Friday, March 15th, 2019

A precise understanding of how the enzyme topoisomerase II cuts DNA could lead to better anti-cancer therapies.

Achilles’ heel for kidney cancer

Monday, March 4th, 2019

A recent study found that renal cell carcinoma cells with mutations in an enzyme-encoding gene, SETD2, were sensitive to a drug that inhibits the enzyme PI3K-beta.

Novel DNA repair mechanism preserves genome integrity: study

Monday, March 4th, 2019

Vanderbilt investigators have discovered a new DNA repair pathway that guards against genomic mutations. Their findings were published recently in the journal Cell.

The yin and yang of cell signaling

Thursday, February 14th, 2019

Changes in enzymes involved in lysophospholipid signaling can activate a pathway implicated in development of cancer, a recent study suggests.

Cell death pathway implicated in bone marrow failure

Monday, February 4th, 2019

Vanderbilt researchers have linked a specific form of programmed cell death to myelodysplastic syndrome, a type of bone marrow failure.

A catalog of DNA replication proteins

Friday, January 25th, 2019

Vanderbilt scientists have identified 593 proteins that are enriched at sites of DNA duplication and chromatin packaging of newly synthesized DNA.

DNA’s on/off switch

Friday, January 18th, 2019

A recent study shows that a component of the DNA primase enzyme acts as a reversible on/off switch for DNA binding and represents a fundamentally new method of communication between DNA-processing enzymes.

Grant enhances study of new chemotherapy targets

Monday, October 22nd, 2018

Vanderbilt chemists have been awarded $7.2 million over the next five years from the National Cancer Institute to lead an initiative to better understand how a combination chemotherapy for breast cancer targets DNA.

Next Page »« Previous Page