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News: Genome Maintenance Research Program

DNA’s on/off switch

Friday, January 18th, 2019

A recent study shows that a component of the DNA primase enzyme acts as a reversible on/off switch for DNA binding and represents a fundamentally new method of communication between DNA-processing enzymes.

Grant enhances study of new chemotherapy targets

Monday, October 22nd, 2018

Vanderbilt chemists have been awarded $7.2 million over the next five years from the National Cancer Institute to lead an initiative to better understand how a combination chemotherapy for breast cancer targets DNA.

Team’s potential lung cancer therapy lands award from SBIR

Thursday, September 27th, 2018

A potential cancer drug aimed at enhancing the effectiveness of ionizing radiation in lung cancer patients is a step closer to development with funding support from the Small Business Innovation Research (SBIR) program.

Energetic gene switch

Tuesday, September 4th, 2018

Vanderbilt researchers have identified a previously undetected type of histone modification that may have implications for cancer and other conditions.

Genetic balancing act

Friday, August 3rd, 2018

A recent study showing that protein called RADX helps regulate the process of DNA repair may help us better understand why some cancers are more or less resistant to certain therapies

Grant bolsters kidney cancer immunotherapy research

Friday, May 11th, 2018

Kimryn Rathmell, MD, PhD, Cornelius Abernathy Craig Professor of Medicine and director of the Division of Hematology and Oncology at Vanderbilt-Ingram Cancer Center (VICC), has received a grant to research the role of immunosuppression in the tumor microenvironment for kidney cancer.

VICC study sheds new light on Von Hippel-Lindau syndrome

Monday, March 12th, 2018

A new study by W. Kimryn Rathmell, MD, PhD, and colleagues, reveals a gene mutation’s role in Von Hippel-Lindau syndrome, a genetically inherited disease which causes tumor growth in several organs.

Rathmell elected to ASCO nominating committee

Tuesday, December 19th, 2017

W. Kimryn Rathmell, MD, PhD, Cornelius A. Craig Professor of Medicine and director of the Division of Hematology and Oncology at Vanderbilt University Medical Center (VUMC), has been elected to the nominating committee of the American Society of Clinical Oncology (ASCO).

DNA damage repair: molecular insights

Thursday, December 7th, 2017

The first line of defense against skin cancer is the ability to repair DNA damage caused by UV light. Walter J. Chazin, PhD, and colleagues investigated how XPA – a protein involved in the repair of certain DNA damage – interacts with DNA and the effects of several disease-associated mutations in XPA on its molecular structure and ability to bind DNA.

Radiation and pulmonary fibrosis

Thursday, November 16th, 2017

Radiation-induced pulmonary fibrosis — tissue scarring that can permanently impair lung function — limits the delivery of therapeutic radiation doses to non-small cell lung cancer. To develop strategies for preventing or reducing fibrosis, Michael Freeman, Ph.D., and colleagues are exploring the cell types and factors that contribute to the radiation-induced fibrotic response.

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