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    Team identifies ‘switch’ involved in DNA replication

    Thursday, February 23rd, 2017

    DNA replication is an extraordinarily complex multi-step process that makes copies of the body’s genetic blueprint. It is necessary for growth and essential to life. Now researchers at the California Institute of Technology (Caltech) and Vanderbilt University have found evidence that one of those steps may involve the telephone-like transmission of electrical signals regulated by […]

    New target for chronic infection

    Thursday, February 2nd, 2017

    The greatest risk factor for gastric cancer is chronic infection by the bacterium, Helicobacter pylori. In a study in mice published by the Proceedings of the National Academy of Sciences, Dana Hardbower, Keith Wilson, M.D., and colleagues found that macrophage activation has a critical role in regulating H. pylori colonization and gastric inflammation. Macrophages are […]

    Colorectal cancer clues

    Thursday, January 26th, 2017

    The colorectum (large intestine) is divided into proximal and distal regions based on differences in embryonic origin, physiological functions and gene expression. Colorectal cancer is heterogeneous depending on its location: for example, proximal tumors have a higher mortality than distal tumors. It is not known, however, whether molecular events contribute to the differences in cancers […]

    Metastatic pancreatic cancer ‘reprograms’ for malignancy

    Thursday, January 19th, 2017

    Metastatic pancreatic cancer — cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths — changes its metabolism and is “reprogrammed” for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics. It may be possible to reverse the malignant reprogramming to treat metastatic pancreatic cancer, […]

    Acting NCI director Lowy to present HPV research lecture

    Thursday, January 12th, 2017

    Douglas R. Lowy, acting director of the National Cancer Institute, will deliver the Vanderbilt-Ingram Cancer Center George Daniel Brooks Lecture at Vanderbilt University Medical Center on Tuesday, Jan. 24, at 11 a.m. in Light Hall, Room 208. The title of the presentation is “Preventing HPV-associated Cancers: Short-term and Long-term Approaches.” Lowy is chief of the […]

    Moses elected to National Academy of Inventors

    Wednesday, January 4th, 2017

    Harold (Hal) Moses, M.D., Ingram Professor of Cancer Research and director emeritus of Vanderbilt-Ingram Cancer Center (VICC), has been named a Fellow of the National Academy of Inventors (NAI). Moses, professor and interim chair of Cancer Biology, is among 175 academic leaders named to the 2016 class of NAI Fellows. Harold L. (Hal) Moses, M.D. […]

    Study to explore lymphedema self care for cancer survivors

    Thursday, December 15th, 2016

    Vanderbilt University School of Nursing (VUSN) Assistant Professor Jie Deng, Ph.D., R.N., has been awarded a $789,000 research scholar grant by the American Cancer Society to develop and test a self-care program for head and neck cancer survivors diagnosed with secondary lymphedema and fibrosis (LEF). LEF causes swelling and the development of hard tissue in […]

    Study links lifestyle factors to formation of high-risk polyps

    Thursday, December 8th, 2016

    Lifestyle factors like cigarette smoking and red meat consumption are known to be associated with an increased risk of colon polyps that can lead to colorectal cancer. Polyps are small growths on the lining of the colon, and while some polyps are harmless others can progress to cancer. A new study led by Vanderbilt University […]

    Targeting the “un-targetable”

    Thursday, December 1st, 2016

    Triple negative breast cancers (TNBC) are so named because they lack common genetic “target” mutations that can be easily treated with specific cancer drugs. However, in a recent study published in Molecular Cancer Therapeutics, Deborah Lannigan, Ph.D., and colleagues investigated a new target involved in TNBC called RSK. They demonstrated that RSK can help cancers […]

    V Foundation grants bolster cancer initiatives

    Thursday, November 17th, 2016

    Two Vanderbilt-Ingram Cancer Center (VICC) investigators have earned grant awards from The V Foundation for Cancer Research, continuing the foundation’s support for innovative cancer research initiatives at VICC. Raymond Blind, Ph.D., assistant professor of Medicine, Biochemistry and Pharmacology, has received a two-year V Foundation grant to examine how proteins induce cancerous tumors to grow. Blind’s […]

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