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    Study links lifestyle factors to formation of high-risk polyps

    Thursday, December 8th, 2016

    Lifestyle factors like cigarette smoking and red meat consumption are known to be associated with an increased risk of colon polyps that can lead to colorectal cancer. Polyps are small growths on the lining of the colon, and while some polyps are harmless others can progress to cancer. A new study led by Vanderbilt University […]

    Targeting the “un-targetable”

    Thursday, December 1st, 2016

    Triple negative breast cancers (TNBC) are so named because they lack common genetic “target” mutations that can be easily treated with specific cancer drugs. However, in a recent study published in Molecular Cancer Therapeutics, Deborah Lannigan, Ph.D., and colleagues investigated a new target involved in TNBC called RSK. They demonstrated that RSK can help cancers […]

    V Foundation grants bolster cancer initiatives

    Thursday, November 17th, 2016

    Two Vanderbilt-Ingram Cancer Center (VICC) investigators have earned grant awards from The V Foundation for Cancer Research, continuing the foundation’s support for innovative cancer research initiatives at VICC. Raymond Blind, Ph.D., assistant professor of Medicine, Biochemistry and Pharmacology, has received a two-year V Foundation grant to examine how proteins induce cancerous tumors to grow. Blind’s […]

    A DARPP role in gastric cancer

    Monday, November 7th, 2016

    Infection with Helicobacter pylori bacterium affects almost half of the world’s population. Chronic infection with H. pylori and its associated inflammation are considered the main risk factors for the development of gastric cancer, the third leading cause of cancer-related deaths worldwide. Previously, Wael El-Rifai, M.D., Ph.D., and colleagues had discovered that DARPP-32 protein, overexpressed in […]

    Single-cell study of tumor samples

    Monday, October 31st, 2016

    The presence of various cell types in tumors – cellular heterogeneity – makes treatment challenging, since a therapy may kill one cell type but not affect another. Studying heterogeneous cell populations requires single-cell analysis. Ken Lau, Ph.D., and colleagues previously described a method for preparing single-cell suspensions from epithelial tissues – the type of tissue […]

    EGF receptor found to regulate macrophage inflammation in gut

    Thursday, October 13th, 2016

    Researchers at Vanderbilt University School of Medicine have uncovered a link between epidermal growth factor receptor (EGFR) signaling and the inflammatory response to bacterial infection in the gastrointestinal tract. In particular, they have found — in mice and human tissue — that EGFR signaling regulates the response of an inflammatory macrophage (a type of white […]

    Vanderbilt scientists to lead chronic disease research initiative in Vietnam

    Thursday, October 6th, 2016

    Scientists in the Vanderbilt Epidemiology Center (VEC) and Vanderbilt-Ingram Cancer Center (VICC) have been awarded a grant to plan and develop a Regional Center of Research Excellence in non-communicable diseases in Vietnam. Xiao Ou Shu, M.D., Ph.D., MPH, associate director for Global Health and co-leader of the Cancer Epidemiology Research Program at VICC, and Thuan […]

    BMI genotype and breast cancer risk

    Thursday, September 29th, 2016

    Being overweight is associated with decreased risk of breast cancer before menopause and increased risk after menopause. In a study published recently in PLOS Medicine, Wei Zheng, Ph.D., M.D., and colleagues investigate these contrasting associations. They use data from 145,056 women, and a list of genetic variants found in genomic studies to be associated with […]

    Restore T cells to fight leukemia

    Thursday, September 15th, 2016

    Acute and chronic B cell leukemia can promote T cell “exhaustion,” which contributes to increased susceptibility to infection and mortality. The treatment-independent mechanisms by which leukemia promotes T cell dysfunction are poorly understood, however. Since metabolic pathways must be tightly regulated to allow normal T cell proliferation and function, Jeffrey Rathmell, Ph.D., Peter Siska, M.D., […]

    Proliferative capacity of neuroblastoma

    Thursday, September 1st, 2016

    Neuroblastoma is a neural crest cell-derived extracranial solid cancer that affects infants and young children. The most vigorous of these cancers spreads through self-renewing cancer stem cells. Knowing the nature of these cells is essential to understanding the progression of neuroblastoma and devising the right treatment strategy. Reporting in the journal Biochemical and Biophysical Research […]

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