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    VICC Annual Scientific Retreat slated for May 4

    Thursday, April 20th, 2017

    Registration Deadline Extended to Thursday, April 27 Leading cancer investigators from several prominent universities and laboratories will headline the 2017 Vanderbilt-Ingram Cancer Center (VICC) Annual Scientific Retreat. Clinicians, scientists, students, staff members and patients are invited to attend the free retreat to be held Thursday, May 4, 8 a.m. – 3 p.m., at the Vanderbilt […]

    A new mode of DNA repair

    Friday, April 14th, 2017

    DNA repair enzymes protect the genome from mutations that can lead to disease. Repair enzymes called DNA glycosylases were recently found to repair DNA interstrand cross-links (ICLs), highly toxic lesions formed by toxins and chemotherapeutic agents. To explore the mechanism for DNA glycosylase-catalyzed ICL removal, Brandt Eichman, Ph.D., and colleagues solved the X-ray crystal structure […]

    Nanobeacon lights up colon tumors

    Sunday, April 2nd, 2017

    The advent of colorectal cancer (CRC) screening, notably colonoscopy, has reduced deaths from this common and deadly malignancy by 30 percent. Unfortunately, colonoscopy misses about 24 percent of small and flat polyps, which often develop into aggressive forms of CRC. Now Wellington Pham, Ph.D., and colleagues report that a novel fluorescent nanobeacon can discern normal […]

    Annual Meharry-Vanderbilt-TSU Cancer Partnership retreat April 8

    Friday, March 24th, 2017

    The Meharry Medical College, Vanderbilt-Ingram Cancer Center (VICC) and Tennessee State University (TSU) Cancer Partnership will host its 16th Annual Cancer Retreat on Saturday, April 8, from 8:30 a.m. to 2:30 p.m. The retreat will be held on the Meharry Medical College campus in the Harold D. West Basic Sciences Building, Room M001. This year’s […]

    Melanoma study finds new way to enhance targeted therapies

    Friday, March 10th, 2017

    With the help of a drug formerly used to treat HIV/AIDS, researchers at Vanderbilt University Medical Center (VUMC) have found a way to make melanoma cells more vulnerable to targeted anti-cancer therapy. Since the AIDS drug is already FDA approved, clinical testing in melanoma patients could potentially begin sooner than if it was a novel […]

    Investigators seek new way to define cell identity

    Monday, March 6th, 2017

    Jonathan Irish, Ph.D., and colleagues have developed a new way to describe and identify cells. (photo by John Russell)Jonathan Irish, Ph.D., and his colleagues have developed a new language, one that can be used to describe and identify cells. The language — marker enrichment modeling, or MEM — assigns a “MEM label” to cells based […]

    Team identifies ‘switch’ involved in DNA replication

    Thursday, February 23rd, 2017

    DNA replication is an extraordinarily complex multi-step process that makes copies of the body’s genetic blueprint. It is necessary for growth and essential to life. Now researchers at the California Institute of Technology (Caltech) and Vanderbilt University have found evidence that one of those steps may involve the telephone-like transmission of electrical signals regulated by […]

    New target for chronic infection

    Thursday, February 2nd, 2017

    The greatest risk factor for gastric cancer is chronic infection by the bacterium, Helicobacter pylori. In a study in mice published by the Proceedings of the National Academy of Sciences, Dana Hardbower, Keith Wilson, M.D., and colleagues found that macrophage activation has a critical role in regulating H. pylori colonization and gastric inflammation. Macrophages are […]

    Colorectal cancer clues

    Thursday, January 26th, 2017

    The colorectum (large intestine) is divided into proximal and distal regions based on differences in embryonic origin, physiological functions and gene expression. Colorectal cancer is heterogeneous depending on its location: for example, proximal tumors have a higher mortality than distal tumors. It is not known, however, whether molecular events contribute to the differences in cancers […]

    Metastatic pancreatic cancer ‘reprograms’ for malignancy

    Thursday, January 19th, 2017

    Metastatic pancreatic cancer — cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths — changes its metabolism and is “reprogrammed” for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics. It may be possible to reverse the malignant reprogramming to treat metastatic pancreatic cancer, […]

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