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    Prostate cancer survivors’ risk of heart disease studied

    Thursday, February 4th, 2016

    The 3 million prostate cancer survivors in the United States are likely to die from something other than cancer, thanks to early detection, effective treatment and the disease’s slow progression. What survivors need to be more concerned with is heart disease, the most common non-cancer cause of death for men with prostate cancer, according to […]

    Study identifies new culprit in lung cancer development

    Thursday, January 28th, 2016

    A microRNA — a small piece of RNA involved in regulating gene expression — functions as an oncogene to drive the development of lung cancer, Vanderbilt University investigators have discovered. The microRNA, known as miR-31, is expressed at high levels in human lung adenocarcinoma, and its expression correlates with reduced patient survival, said Christine Eischen, […]

    Copying chromosome caps

    Friday, January 8th, 2016

    DNA replication – the process of copying the DNA each time a cell divides – faces many sources of stress, such as DNA damage and sequences that are difficult to copy. A family of related enzymes, including SMARCAL1, responds to replication stress to stabilize, repair and restart stalled replication “forks.” David Cortez, Ph.D., and colleagues […]

    New lead for ovarian cancer treatment

    Friday, December 11th, 2015

    Despite increasingly advanced treatments, nearly half the women who contract ovarian cancer will die within five years. Chemotherapy drug resistance significantly contributes to the high mortality rate. Understanding the processes that trigger tumor growth allows scientists to find better ways to treat this disease. Members of the laboratory of Hal Moses, M.D., previously identified the […]

    Computer extracts cancer stage

    Friday, November 13th, 2015

    Cancer stage, an important element in prognosis, is often documented in narrative form in medical records, which leads to time-consuming abstraction by tumor registry personnel and other secondary users of these records. Jeremy Warner, M.D., M.S., and colleagues developed a computerized natural language processing algorithm to extract cancer stages from electronic medical records. Records from […]

    Investigators find clues to melanoma treatment resistance

    Friday, October 30th, 2015

    Nearly half of all patients with malignant melanoma, the most deadly form of skin cancer, have a mutation in the BRAF gene found in their tumors. Mutations in the BRAF gene turn on a cancer growth switch known as the MAP kinase pathway. In recent years, new drugs have been approved that target the BRAF/MAPK […]

    Biomarker for intestinal tumors

    Thursday, October 22nd, 2015

    The incidence of pancreatic and small intestinal neuroendocrine tumors (NETs) has risen over the past decade. NETs are the second most common cancers in the small intestine and pancreas and are frequently associated with liver metastasis. Safia Salaria, M.D., and colleagues examined expression of CD24 – a biomarker for normal and cancer stem cells – […]

    Study shows compression device helps ease lymphedema

    Friday, October 9th, 2015

    Lymphedema patients saw a nearly 80 percent reduction in cellulitis episodes by using an advanced pneumatic compression device at home, according to a study in JAMA Dermatology co-authored by Vanderbilt University School of Nursing’s Sheila Ridner, Ph.D., and University of Minnesota School of Public Health Associate Professor Pinar Karaca-Mandic, Ph.D. The reduction in episodes also led […]

    Potential target for lung cancer therapy

    Friday, October 9th, 2015

    A protein that transports the amino acid glutamine is a potential biomarker and therapeutic target for non-small cell lung cancer, Vanderbilt researchers reported in the Oct. 1 International Journal of Cancer. Pierre Massion, M.D., and colleagues previously demonstrated that the protein SLC1A5 is the primary transporter of glutamine – a modulator of cell growth and oxidative […]

    Reduced-nicotine cigarettes decreased dependence and frequency of smoking

    Thursday, October 1st, 2015

    Reduced-nicotine cigarettes were beneficial in reducing nicotine exposure and dependence, and also the number of cigarettes smoked per day, when compared with standard-nicotine cigarettes in a six-week study published in the New England Journal of Medicine. It is the first large-scale clinical trial to examine the effects of reduced-nicotine cigarettes on smoking behavior and exposure […]

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