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    EGF receptor found to regulate macrophage inflammation in gut

    Thursday, October 13th, 2016

    Researchers at Vanderbilt University School of Medicine have uncovered a link between epidermal growth factor receptor (EGFR) signaling and the inflammatory response to bacterial infection in the gastrointestinal tract. In particular, they have found — in mice and human tissue — that EGFR signaling regulates the response of an inflammatory macrophage (a type of white […]

    Vanderbilt scientists to lead chronic disease research initiative in Vietnam

    Thursday, October 6th, 2016

    Scientists in the Vanderbilt Epidemiology Center (VEC) and Vanderbilt-Ingram Cancer Center (VICC) have been awarded a grant to plan and develop a Regional Center of Research Excellence in non-communicable diseases in Vietnam. Xiao Ou Shu, M.D., Ph.D., MPH, associate director for Global Health and co-leader of the Cancer Epidemiology Research Program at VICC, and Thuan […]

    BMI genotype and breast cancer risk

    Thursday, September 29th, 2016

    Being overweight is associated with decreased risk of breast cancer before menopause and increased risk after menopause. In a study published recently in PLOS Medicine, Wei Zheng, Ph.D., M.D., and colleagues investigate these contrasting associations. They use data from 145,056 women, and a list of genetic variants found in genomic studies to be associated with […]

    Restore T cells to fight leukemia

    Thursday, September 15th, 2016

    Acute and chronic B cell leukemia can promote T cell “exhaustion,” which contributes to increased susceptibility to infection and mortality. The treatment-independent mechanisms by which leukemia promotes T cell dysfunction are poorly understood, however. Since metabolic pathways must be tightly regulated to allow normal T cell proliferation and function, Jeffrey Rathmell, Ph.D., Peter Siska, M.D., […]

    Proliferative capacity of neuroblastoma

    Thursday, September 1st, 2016

    Neuroblastoma is a neural crest cell-derived extracranial solid cancer that affects infants and young children. The most vigorous of these cancers spreads through self-renewing cancer stem cells. Knowing the nature of these cells is essential to understanding the progression of neuroblastoma and devising the right treatment strategy. Reporting in the journal Biochemical and Biophysical Research […]

    New breast cancer driver

    Friday, August 26th, 2016

    Approximately 20 percent of breast cancers have overexpression of the protein HER2, which drives signaling by the protein kinase Akt and is a marker of aggressive disease. The protein complex Rictor/mTORC2 is a known activator of Akt, but its role in breast cancer formation, progression and treatment is unclear. Rebecca Cook, Ph.D., and colleagues have […]

    Chicken Salad Chick Foundation Gift to Support VICC Research

    Wednesday, August 17th, 2016

    Chicken Salad Chick Foundation founding board members Stacy Brown and Betty and Earlon McWhorter presented a $200,000 check to Vanderbilt-Ingram Cancer Center (VICC) to support cancer research. Among other initiatives, the Chicken Salad Chick Foundation was proud to host Music and Miracles Superfest, the first major stadium concert in Jordan-Hare’s 75-year history, held on April […]

    Kleberg Foundation grant bolsters cancer drug discovery efforts

    Thursday, August 4th, 2016

    The Robert J. Kleberg Jr. and Helen C. Kleberg Foundation has awarded a $3 million grant to Vanderbilt-Ingram Cancer Center (VICC) investigators in support of VICC’s drug discovery program. The gift awarded over the next three years from the private, San Antonio, Texas-based foundation will enable VICC researchers to pursue the development of new compounds […]

    Breast cancer: finding the smoking gun

    Thursday, July 21st, 2016

    Many genes are associated with cancer. The trick is proving they actually promote tumor formation. One approach, detailed by Ian Macara, Ph.D., and colleagues last month in Cell Reports, is an in vivo “gain-of-function” screen. The researchers used a gene “library” (complementary DNA carried by lentivirus) to increase the expression of nearly 1000 different genes […]

    VICC leads study on high breast cancer incidence and mortality rates in African-American women

    Wednesday, July 6th, 2016

    A cancer research consortium headed by investigators at Vanderbilt-Ingram Cancer Center (VICC) and two other institutions, today received $12 million in federal funding to help determine why African-American women die at a higher rate and have more aggressive breast cancer than white women.  The grant, which was awarded by the National Cancer Institute (NCI), part […]

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