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    Bad “traffic” linked to cancer

    Thursday, September 3rd, 2015

    The epidermal growth factor receptor (EGFR) is activated in different locations in the cell by different proteins called ligands. Transporting ligands to the wrong places, called mistrafficking, is associated with abnormal signaling and cancer. Polarized columnar epithelial cells have an “apical” surface that faces the lumen, or body cavities, and a “basolateral” surface that faces […]

    Drug combos enhance ovarian cancer cell death

    Monday, August 24th, 2015

    Ovarian cancer is often diagnosed at an advanced stage and frequently develops resistance to platinum chemotherapy. Identifying new drug combinations to overcome platinum resistance is a critical clinical challenge. They report in the Journal of Ovarian Research that combined thymoquinone and cisplatin had synergistic anti-tumor effects in cultured cells. The drug combination reduced tumor burden and […]

    Origins of neuroblastoma

    Monday, August 24th, 2015

    Neuroblastoma – a pediatric cancer of the sympathetic (“fight or flight”) nerve ganglia and adrenal glands – is thought to originate from the cells that give rise to the developing sympathetic nervous system. Amplification of the MYCN oncogene is associated with risk in this disease, but its role in the early steps of neuroblastoma initiation […]

    Stomach cancer cues

    Friday, August 7th, 2015

    Stomach cancer is one of the most frequent cancers in the world and does not usually respond well to current treatments. Understanding how stomach cancer develops could provide new opportunities for treatment. Reporting last month in the journal Oncogene, Wael El-Rifai, M.D., Ph.D., and colleagues have discovered a new molecular mechanism involving the protein DARPP-32 […]

    Anticancer olive compounds

    Thursday, July 30th, 2015

    Natural compounds from plants – phytochemicals – provide a variety of health benefits, including anticancer activity. The human topoisomerases, enzymes that “detangle” DNA, are important targets for plant-derived anticancer drugs. To discover novel phytochemicals with anticancer activity, Kendra Vann, Neil Osheroff, Ph.D., and colleagues screened a library of 341 Mediterranean plant extracts for activity against […]

    Study reveals how protein helps cells tolerate DNA damage

    Thursday, July 16th, 2015

    Every day, cells in our bodies copy their DNA — about 6 billion “letters” worth — and divide. DNA replication is a fundamental process in biology, but it isn’t fully understood, said Brandt Eichman, Ph.D., associate professor of Biological Sciences and Biochemistry. And it doesn’t always proceed smoothly. DNA damage and other problems in the […]

    Healthy Diet Linked to Lower Death Rates Among Low-Income Residents in Southeastern U.S.

    Monday, June 29th, 2015

    Eating a healthy diet was linked with a lower risk of dying from heart disease, stroke, cancer or other diseases among a population of low-income individuals living in the Southeastern U.S., according to research led by Vanderbilt University investigators. Nearly two-thirds of the participants in the study were African-American. The study by first author Danxia […]

    Study finds significant drop in new prostate cancer diagnoses

    Friday, June 19th, 2015

    A new study led by Vanderbilt University Medical Center investigators found new diagnoses of prostate cancer in the U.S. declined 28 percent in the year following the draft recommendation from the United States Preventive Services Task Force (USPSTF) against routine PSA screening for men. The new research, led by first author Daniel Barocas, M.D., MPH, […]

    Exploring Accountable Care Organizations’ impact on cancer screenings

    Friday, May 29th, 2015

    As health care organizations implement new strategies to improve quality and reduce costs, a physician researcher at VUMC is setting out to identify whether there could be unintended effects. Matthew Resnick, M.D., MPH, assistant professor of Urologic Surgery and Health Policy, has been awarded a $726,000 grant from the American Cancer Society to study the […]

    Tools for exploring ‘omics’ data

    Thursday, May 21st, 2015

    Advances in technology have generated vast amounts of “omics” data: genomic, epigenomic, transcriptomic, proteomic and metabolomic changes for all types of specimens. Bridging the gap between data generation and investigators’ ability to retrieve and interpret data is essential to realize the biological and clinical value of this wealth of information. Bing Zhang, Ph.D., and colleagues […]

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