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    Metastatic pancreatic cancer ‘reprograms’ for malignancy

    Thursday, January 19th, 2017

    Metastatic pancreatic cancer — cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths — changes its metabolism and is “reprogrammed” for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics. It may be possible to reverse the malignant reprogramming to treat metastatic pancreatic cancer, […]

    Acting NCI director Lowy to present HPV research lecture

    Thursday, January 12th, 2017

    Douglas R. Lowy, acting director of the National Cancer Institute, will deliver the Vanderbilt-Ingram Cancer Center George Daniel Brooks Lecture at Vanderbilt University Medical Center on Tuesday, Jan. 24, at 11 a.m. in Light Hall, Room 208. The title of the presentation is “Preventing HPV-associated Cancers: Short-term and Long-term Approaches.” Lowy is chief of the […]

    Moses elected to National Academy of Inventors

    Wednesday, January 4th, 2017

    Harold (Hal) Moses, M.D., Ingram Professor of Cancer Research and director emeritus of Vanderbilt-Ingram Cancer Center (VICC), has been named a Fellow of the National Academy of Inventors (NAI). Moses, professor and interim chair of Cancer Biology, is among 175 academic leaders named to the 2016 class of NAI Fellows. Harold L. (Hal) Moses, M.D. […]

    Study to explore lymphedema self care for cancer survivors

    Thursday, December 15th, 2016

    Vanderbilt University School of Nursing (VUSN) Assistant Professor Jie Deng, Ph.D., R.N., has been awarded a $789,000 research scholar grant by the American Cancer Society to develop and test a self-care program for head and neck cancer survivors diagnosed with secondary lymphedema and fibrosis (LEF). LEF causes swelling and the development of hard tissue in […]

    Study links lifestyle factors to formation of high-risk polyps

    Thursday, December 8th, 2016

    Lifestyle factors like cigarette smoking and red meat consumption are known to be associated with an increased risk of colon polyps that can lead to colorectal cancer. Polyps are small growths on the lining of the colon, and while some polyps are harmless others can progress to cancer. A new study led by Vanderbilt University […]

    Targeting the “un-targetable”

    Thursday, December 1st, 2016

    Triple negative breast cancers (TNBC) are so named because they lack common genetic “target” mutations that can be easily treated with specific cancer drugs. However, in a recent study published in Molecular Cancer Therapeutics, Deborah Lannigan, Ph.D., and colleagues investigated a new target involved in TNBC called RSK. They demonstrated that RSK can help cancers […]

    V Foundation grants bolster cancer initiatives

    Thursday, November 17th, 2016

    Two Vanderbilt-Ingram Cancer Center (VICC) investigators have earned grant awards from The V Foundation for Cancer Research, continuing the foundation’s support for innovative cancer research initiatives at VICC. Raymond Blind, Ph.D., assistant professor of Medicine, Biochemistry and Pharmacology, has received a two-year V Foundation grant to examine how proteins induce cancerous tumors to grow. Blind’s […]

    A DARPP role in gastric cancer

    Monday, November 7th, 2016

    Infection with Helicobacter pylori bacterium affects almost half of the world’s population. Chronic infection with H. pylori and its associated inflammation are considered the main risk factors for the development of gastric cancer, the third leading cause of cancer-related deaths worldwide. Previously, Wael El-Rifai, M.D., Ph.D., and colleagues had discovered that DARPP-32 protein, overexpressed in […]

    Single-cell study of tumor samples

    Monday, October 31st, 2016

    The presence of various cell types in tumors – cellular heterogeneity – makes treatment challenging, since a therapy may kill one cell type but not affect another. Studying heterogeneous cell populations requires single-cell analysis. Ken Lau, Ph.D., and colleagues previously described a method for preparing single-cell suspensions from epithelial tissues – the type of tissue […]

    EGF receptor found to regulate macrophage inflammation in gut

    Thursday, October 13th, 2016

    Researchers at Vanderbilt University School of Medicine have uncovered a link between epidermal growth factor receptor (EGFR) signaling and the inflammatory response to bacterial infection in the gastrointestinal tract. In particular, they have found — in mice and human tissue — that EGFR signaling regulates the response of an inflammatory macrophage (a type of white […]

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