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    Cancer prevention and poverty

    Friday, April 1st, 2016

    Interested in how cancer prevention recommendations play out in low-income populations, epidemiologist Shaneda Warren Anderson, Ph.D., and colleagues analyzed data from 61,098 adults, with overrepresentation of low-income whites and African-Americans. The team measured adherence to American Cancer Society (ACS) recommendations regarding body mass index, physical activity, diet, alcohol intake and smoking status, and they gathered […]

    New role identified for p73 gene

    Friday, April 1st, 2016

    The p53 gene is a tumor suppressor whose absence or silence contributes to cancer formation. Vanderbilt-Ingram Cancer Center investigators recently defined the role of a family member – p73. Using a p73-deficient mouse model developed in the laboratory of Jennifer Pietenpol, Ph.D., investigators led by Clayton Marshall found that p73 regulates at least 100 genes […]

    ROCKs and cancer invasion

    Thursday, March 17th, 2016

    Cancers become fatal mostly because of their ability to spread. Cancerous cells migrate from primary tumors and invade neighboring tissues through protrusions called invadopodia. The rigidity of the cancerous mass, the tumor-associated extracellular matrix (ECM), drives malignant behavior through the Rho/ROCK signaling pathway. In particular, the ROCK protein is mutated and overexpressed in many cancers, […]

    A clue to cell cleavage

    Thursday, March 10th, 2016

    The final step of cell division is termed cytokinesis, a process that separates one cell into two. Cytokinesis is linked to events underlying cancer and the development of diverse cell types in the human body. The cytoskeleton, networks of filamentous proteins, is key for cytokinesis. Microtubules form a barrel-shaped array called the spindle midzone, which […]

    Melanoma response to immune therapy

    Friday, March 4th, 2016

    Anti-PD-1 therapy – a treatment that stimulates the immune system to attack tumors – produces responses in up to 40 percent of melanoma patients. Predictive markers of response are needed to optimize patient selection, improve treatment decision-making and minimize costs. Justin Balko, Pharm.D., Ph.D., Douglas Johnson, M.D., and colleagues hypothesized that tumor expression of MHC-I […]

    Chemo better option following pancreatic cancer surgery: study

    Thursday, February 25th, 2016

    A multicenter study led by Vanderbilt University Medical Center (VUMC) investigators found that pancreatic cancer patients who underwent surgery and received chemotherapy lived longer and had fewer cancer recurrences in other parts of the body than patients who also received chemoradiation therapy. The study led by Alexander Parikh, M.D., MPH, associate professor of Surgery and […]

    Study explores less invasive way to monitor colorectal cancer

    Monday, February 22nd, 2016

    Investigators at Vanderbilt University Medical Center have published research regarding an important feature of colorectal cancer (CRC) that could eventually lead to the development of non-invasive means of monitoring cancer progression. After lung cancer, CRC is the second-most lethal cancer in the United States. The team’s research, published in eLIFE, indicates that colorectal cancer cells […]

    Study identifies potential colon cancer biomarker

    Thursday, February 11th, 2016

    A protein that suppresses a key cancer pathway in the colon may be a potential biomarker for colitis-associated tumors, researchers at Vanderbilt University Medical Center reported last month in the journal Gut. The protein, called blood vessel epicardial substance or BVES, also may be a new therapeutic target for cancers in the colon and elsewhere, […]

    Prostate cancer survivors’ risk of heart disease studied

    Thursday, February 4th, 2016

    The 3 million prostate cancer survivors in the United States are likely to die from something other than cancer, thanks to early detection, effective treatment and the disease’s slow progression. What survivors need to be more concerned with is heart disease, the most common non-cancer cause of death for men with prostate cancer, according to […]

    Study identifies new culprit in lung cancer development

    Thursday, January 28th, 2016

    A microRNA — a small piece of RNA involved in regulating gene expression — functions as an oncogene to drive the development of lung cancer, Vanderbilt University investigators have discovered. The microRNA, known as miR-31, is expressed at high levels in human lung adenocarcinoma, and its expression correlates with reduced patient survival, said Christine Eischen, […]

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