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    A clue to cell cleavage

    Thursday, March 10th, 2016

    The final step of cell division is termed cytokinesis, a process that separates one cell into two. Cytokinesis is linked to events underlying cancer and the development of diverse cell types in the human body. The cytoskeleton, networks of filamentous proteins, is key for cytokinesis. Microtubules form a barrel-shaped array called the spindle midzone, which […]

    Melanoma response to immune therapy

    Friday, March 4th, 2016

    Anti-PD-1 therapy – a treatment that stimulates the immune system to attack tumors – produces responses in up to 40 percent of melanoma patients. Predictive markers of response are needed to optimize patient selection, improve treatment decision-making and minimize costs. Justin Balko, Pharm.D., Ph.D., Douglas Johnson, M.D., and colleagues hypothesized that tumor expression of MHC-I […]

    Chemo better option following pancreatic cancer surgery: study

    Thursday, February 25th, 2016

    A multicenter study led by Vanderbilt University Medical Center (VUMC) investigators found that pancreatic cancer patients who underwent surgery and received chemotherapy lived longer and had fewer cancer recurrences in other parts of the body than patients who also received chemoradiation therapy. The study led by Alexander Parikh, M.D., MPH, associate professor of Surgery and […]

    Study explores less invasive way to monitor colorectal cancer

    Monday, February 22nd, 2016

    Investigators at Vanderbilt University Medical Center have published research regarding an important feature of colorectal cancer (CRC) that could eventually lead to the development of non-invasive means of monitoring cancer progression. After lung cancer, CRC is the second-most lethal cancer in the United States. The team’s research, published in eLIFE, indicates that colorectal cancer cells […]

    Study identifies potential colon cancer biomarker

    Thursday, February 11th, 2016

    A protein that suppresses a key cancer pathway in the colon may be a potential biomarker for colitis-associated tumors, researchers at Vanderbilt University Medical Center reported last month in the journal Gut. The protein, called blood vessel epicardial substance or BVES, also may be a new therapeutic target for cancers in the colon and elsewhere, […]

    Prostate cancer survivors’ risk of heart disease studied

    Thursday, February 4th, 2016

    The 3 million prostate cancer survivors in the United States are likely to die from something other than cancer, thanks to early detection, effective treatment and the disease’s slow progression. What survivors need to be more concerned with is heart disease, the most common non-cancer cause of death for men with prostate cancer, according to […]

    Study identifies new culprit in lung cancer development

    Thursday, January 28th, 2016

    A microRNA — a small piece of RNA involved in regulating gene expression — functions as an oncogene to drive the development of lung cancer, Vanderbilt University investigators have discovered. The microRNA, known as miR-31, is expressed at high levels in human lung adenocarcinoma, and its expression correlates with reduced patient survival, said Christine Eischen, […]

    Copying chromosome caps

    Friday, January 8th, 2016

    DNA replication – the process of copying the DNA each time a cell divides – faces many sources of stress, such as DNA damage and sequences that are difficult to copy. A family of related enzymes, including SMARCAL1, responds to replication stress to stabilize, repair and restart stalled replication “forks.” David Cortez, Ph.D., and colleagues […]

    New lead for ovarian cancer treatment

    Friday, December 11th, 2015

    Despite increasingly advanced treatments, nearly half the women who contract ovarian cancer will die within five years. Chemotherapy drug resistance significantly contributes to the high mortality rate. Understanding the processes that trigger tumor growth allows scientists to find better ways to treat this disease. Members of the laboratory of Hal Moses, M.D., previously identified the […]

    Computer extracts cancer stage

    Friday, November 13th, 2015

    Cancer stage, an important element in prognosis, is often documented in narrative form in medical records, which leads to time-consuming abstraction by tumor registry personnel and other secondary users of these records. Jeremy Warner, M.D., M.S., and colleagues developed a computerized natural language processing algorithm to extract cancer stages from electronic medical records. Records from […]

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