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    Data mining reveals cancer-driving genes

    Thursday, January 22nd, 2015

    Prospecting for genes that might be implicated in cancer, a Vanderbilt University Medical Center research team has struck pay dirt. Zhongming Zhao, Ph.D., Peilin Jia, Ph.D., and colleagues use novel computational methods to sift through online repositories of molecular data gathered by cancer researchers worldwide. These results, and further analyses planned by the team, can […]

    Enzyme affects tumor metastasis

    Thursday, January 8th, 2015

    Breast cancer remains the most common type of cancer in females, with survival rates decreasing sharply for those with distant metastases. MMP2, a type of enzyme that degrades the extracellular matrix, has previously been implicated in the development of distant tumor metastases, but without a clearly defined role. In the Journal of Pathology, Barbara Fingleton, […]

    Combo therapy may help fight melanoma

    Thursday, January 8th, 2015

    Two therapies already in clinical development as single agents may work in combination to treat many subtypes of melanoma, a recent study suggests.

    Potential Prostate Cancer Blood Test

    Tuesday, January 6th, 2015

    Vanderbilt University researcher William Mitchell, M.D., Ph.D., and colleagues in Germany and Canada have demonstrated a method for detecting “cell-free” tumor DNA in the bloodstream.

    New insight on oral cancer culprits

    Wednesday, November 12th, 2014

    Oral squamous cell carcinoma (OSCC) treatments have been slow to advance despite the aggressive nature of these tumors that commonly metastasize. Models for the development of improved OSCC therapeutics have also been scarce. Thomas Andl, Ph.D., Claudia Andl, Ph.D., and colleagues previously observed coordinated loss of connective molecules (E-cadherin) and growth factor (TGFbeta) signaling in […]

    Study Finds New Role for Cell Factor

    Friday, October 31st, 2014

    Vanderbilt University investigators have discovered a new molecular mechanism that regulates the dynamics of microtubules, which form the cell’s internal skeleton. The unexpected finding, reported in Developmental Cell, has implications for cancer drug discovery,

    Aspirin’s Protective Effect in Cancer Explained

    Thursday, October 2nd, 2014

    For years, scientists have known that regular aspirin use may reduce the risk of cancer. “Studies have shown that aspirin administration for five or more years reduces the incidence of all cancers by 38 percent,” said Pierre Massion, M.D., professor of Medicine and Cancer Biology and director of the Thoracic Program at Vanderbilt-Ingram Cancer Center. […]

    Accuracy of Lung Imaging Varies by Region

    Wednesday, September 24th, 2014

    FDG-PET technology is less accurate in diagnosing lung cancer versus benign disease in regions where infections like histoplasmosis or tuberculosis are common, a recent study has found.

    Study identifies genes tied to colon cancer

    Friday, August 22nd, 2014

    by Dagny Stuart Colorectal cancer is one of the leading causes of death among populations around the world. While diet, physical activity and other lifestyle factors can influence the risk of developing the disease, hereditary factors also play an important role. Genetic factors identified to date explain only a small fraction of colorectal cancer (CRC), […]

    Komen breast cancer research grants

    Friday, August 1st, 2014

    by Dagny Stuart Two Vanderbilt-Ingram Cancer Center investigators have received multi-year breast cancer research grants from the Susan G. Komen for the Cure Breast Cancer Foundation. Justin Balko, Ph.D., Pharm.D., research assistant professor of Medicine, won support for his research project which will use molecular profiling to prioritize adjuvant targeted therapy for triple negative breast […]

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