A protein that transports the amino acid glutamine is a potential biomarker and therapeutic target for non-small cell lung cancer, Vanderbilt researchers reported in the Oct. 1 International Journal of Cancer. Pierre Massion, M.D., and colleagues previously demonstrated that the protein SLC1A5 is the primary transporter of glutamine – a modulator of cell growth and oxidative […]
News: Lung Cancer
Anti-cancer drugs are typically tested on one type of cancer at a time. But an international consortium of cancer investigators, including Vanderbilt-Ingram Cancer Center (VICC) researchers, simultaneously tested an existing therapy in patients with several different forms of cancer that all exhibit the same tumor gene mutation. The new clinical trial showed promising results in […]
In a town full of amazing singers, Nashville songstress Dawn Sears’ voice was something special. Among the music professionals who tour with superstars and perform in Nashville recording sessions, Sears was celebrated for a voice of crystalline purity. The “Dawn Sears and Friends” event, emceed by Olympic figure skater and cancer survivor Scott Hamilton, and […]
Pierre Massion, M.D., director of the Thoracic Program and an Ingram Professor of Cancer Research at Vanderbilt-Ingram Cancer Center, has been recognized for his pioneering work in lung cancer by the LUNGevity Foundation. During his six-year tenure as chair of that board, Massion helped guide the foundation’s grant funding program.The foundation named him the June […]
Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer. Abnormal regulation of this pathway leads to several human malignancies, including small cell lung cancer and pancreatic cancer, and therefore it is a potential drug target for cancer. Small molecules have […]
Vanderbilt-Ingram Cancer Center investigators have identified the mechanisms used by a gene and its binding protein to drive tumor growth in several forms of cancer, including non-small cell lung cancer. In a report published online recently in the Proceedings of the National Academy of Sciences (PNAS), first author Jun Qian, Ph.D., lead investigator Pierre Massion, M.D., […]
November is well-known as Lung Cancer Awareness Month. It is also the month that highlights awareness of less publicized forms of cancer including pancreatic cancer and stomach cancer. All three of these diseases share a common risk factor — cigarette smoking. “Smoking is the leading cause of preventable disease and death and it is claiming […]
Somatic mutations, which can occur in any cell except sperm or egg, are not inheritable. Several recent studies have demonstrated that disease-causing mutations commonly alter protein folding, protein stability and protein-protein interactions. It has been difficult, however, to determine which somatic mutations identified in tumor samples “drive” the cancer development and which are just “along […]
FDG-PET technology is less accurate in diagnosing lung cancer versus benign disease in regions where infections like histoplasmosis or tuberculosis are common, a recent study has found.
Joe B. (Bill) Putnam Jr., M.D., Ingram Professor of Cancer Research and chair of the Department of Thoracic Surgery, and colleague Felix Fernandez, M.D., assistant professor of Surgery, Emory University School of Medicine, Atlanta, have received a grant to investigate the most effective forms of surgery to treat lung cancer patients.