Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer. Abnormal regulation of this pathway leads to several human malignancies, including small cell lung cancer and pancreatic cancer, and therefore it is a potential drug target for cancer. Small molecules have […]
News: Lung Cancer
Vanderbilt-Ingram Cancer Center investigators have identified the mechanisms used by a gene and its binding protein to drive tumor growth in several forms of cancer, including non-small cell lung cancer. In a report published online recently in the Proceedings of the National Academy of Sciences (PNAS), first author Jun Qian, Ph.D., lead investigator Pierre Massion, M.D., […]
November is well-known as Lung Cancer Awareness Month. It is also the month that highlights awareness of less publicized forms of cancer including pancreatic cancer and stomach cancer. All three of these diseases share a common risk factor — cigarette smoking. “Smoking is the leading cause of preventable disease and death and it is claiming […]
Somatic mutations, which can occur in any cell except sperm or egg, are not inheritable. Several recent studies have demonstrated that disease-causing mutations commonly alter protein folding, protein stability and protein-protein interactions. It has been difficult, however, to determine which somatic mutations identified in tumor samples “drive” the cancer development and which are just “along […]
FDG-PET technology is less accurate in diagnosing lung cancer versus benign disease in regions where infections like histoplasmosis or tuberculosis are common, a recent study has found.
Joe B. (Bill) Putnam Jr., M.D., Ingram Professor of Cancer Research and chair of the Department of Thoracic Surgery, and colleague Felix Fernandez, M.D., assistant professor of Surgery, Emory University School of Medicine, Atlanta, have received a grant to investigate the most effective forms of surgery to treat lung cancer patients.
Lung cancer patients with specific gene alterations may benefit from combination therapy that targets two different cancer pathways, a recent study suggests.
A new study estimates that tobacco smoking has been linked to approximately 2 million deaths among adult men and women in Asia in recent years and predicts a rising death toll. The study, published in PLOS Medicine, was led by Wei Zheng, M.D., Ph.D., MPH, professor of Medicine and director of the Vanderbilt Epidemiology Center, […]
Vanderbilt-Ingram Cancer Center has launched a new lung cancer screening program to provide low-dose CT scans for patients at high risk for the deadly disease. Current or former smokers ages 55 to 74 who have a history of 30 or more pack years of smoking are eligible for the scans. A pack year is defined […]
Christine Lovly, M.D., Ph.D., instructor in Medicine at the Vanderbilt University School of Medicine, has earned the 2013 Damon Runyon Clinical Investigator Award, which supports young physician-scientists conducting patient-oriented cancer research. The three-year award will provide $450,000 for Lovly’s research efforts in lung cancer. “I am so honored to receive this prestigious and competitive award […]