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News: Research

Symposium honors Moses’ storied cancer research career

Friday, October 20th, 2017

Members of the Vanderbilt University Medical Center (VUMC) community and others whose lives and careers have been influenced by legendary cancer investigator, educator and administrator Harold (Hal) Moses, M.D., have endowed the Linda and Harold L. Moses, M.D., Career Development Fund.

Researchers find novel mechanism of resistance to anti-cancer drugs

Friday, October 20th, 2017

The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States. However, many patients have tumors with genetic mutations that make them resistant to these anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, or the cancers develop resistance during treatment.

Special symposium to honor Moses’ cancer research contributions

Friday, September 22nd, 2017

A research symposium honoring the career of Harold (Hal) Moses, M.D., who founded and served as director emeritus of Vanderbilt-Ingram Cancer Center, has been slated for Wednesday, Oct. 11, 7:45 a.m. – 3:30 p.m., at the Vanderbilt Student Life Center.

Acid reflux cancer link

Sunday, September 17th, 2017

In a study published in the journal Scientific Reports, Alexander Zaika, Ph.D. and coworkers show that DNA damage in the esophageal cells caused by acidic bile reflux (BA/A) activates enzymes called NADPH oxidases in the mitochondria, the cell’s power house, to release highly reactive-oxygen species (ROS).

Pancreatic cancer development

Saturday, September 2nd, 2017

Pancreatic ductal carcinoma (PDAC) is one of the most lethal types of cancer, with new therapeutic options needed. Sergey Novitskiy, M.D., Ph.D., and colleagues investigated the immune response during the development of aggressive PDAC in an animal model of the disease.

Fatty acids and adenoma risk

Monday, August 28th, 2017

Dietary intake of polyunsaturated fatty acids (PUFAs) has been associated with risk of colorectal cancer, with omega-6 PUFAs increasing and omega-3 PUFAs decreasing risk. Most studies, however, have relied on questionnaires to assess consumption of fatty acids, and results have been inconsistent. Harvey Murff, M.D., and colleagues have studied a blood-based biomarker of PUFA intake. […]

Hyundai Hope on Wheels award boosts pediatric cancer research

Monday, August 28th, 2017

Adam Esbenshade, M.D., MSCI, assistant professor of Pediatrics in the Division of Pediatric Hematology/Oncology, has been awarded a $50,000 Hyundai Hope on Wheels Impact Award. Esbenshade plans to use data to create a risk prediction model to predict blood stream infections in pediatric cancer patients. The grant was celebrated in a “handprint ceremony” on Aug. […]

Report identifies IT upgrades needed to enhance cancer care

Friday, August 18th, 2017

A group of nationally recognized medical information and data management experts has recommended the development of new knowledge software applications that work alongside electronic health record systems (EHRs) to help practicing oncologists access and use the latest genomic information to assist in the treatment of cancer patients. The recommendations were unveiled in a new report […]

Cancer-fighting T cells are smarter, stronger than experts thought

Friday, August 18th, 2017

Scientists studying the body’s cancer-fighting T cells have a serious problem: When they culture them in the lab, the T cells sit around at equilibrium, waiting to bump into cancerous cells. But that’s not how they operate inside the body. There, they are motorized little bloodhounds, actively seeking out infected cells. In this active mode, […]

Breast Cancer Genomic Profiling Reveals Clues to Treatment Resistance

Friday, August 11th, 2017

Thanks to advances in treatment, the relative five-year survival rate from all combined subtypes of breast cancer now exceeds 90 percent and yet the disease remains the third leading cause of cancer deaths in the United States after lung and colorectal cancers. Carlos L. Arteaga, M.D. More than 40,000 American women will die from breast […]

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