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News: Research

Correctly copying DNA

Friday, March 15th, 2019

A precise understanding of how the enzyme topoisomerase II cuts DNA could lead to better anti-cancer therapies.

Cancer Center Ambassadors surpass $1 million in grants

Friday, March 15th, 2019

Vanderbilt-Ingram Cancer Center Ambassadors surpassed the $1 million mark with the awarding of the group’s latest research grants.

Achilles’ heel for kidney cancer

Monday, March 4th, 2019

A recent study found that renal cell carcinoma cells with mutations in an enzyme-encoding gene, SETD2, were sensitive to a drug that inhibits the enzyme PI3K-beta.

Lighting up colorectal cancer

Monday, March 4th, 2019

Wellington Pham, PhD, and colleagues in Japan, have developed a nanobeacon imaging agent to aid the early detection of colorectal cancer during colonoscopy.

Protein loss promotes cell migration

Monday, March 4th, 2019

The protein STK17A (serine threonine kinase 17A) appears to play roles in various cancer types. Researchers have found that cells without STK17A become less connected and more invasive.

Investigators map genomic landscape of very rare cancer

Monday, March 4th, 2019

Vanderbilt researchers have mapped out the genomic landscape of a metastatic malignant proliferating tricholemmal tumor and identified a targeted treatment for this very rare cancer.

Novel DNA repair mechanism preserves genome integrity: study

Monday, March 4th, 2019

Vanderbilt investigators have discovered a new DNA repair pathway that guards against genomic mutations. Their findings were published recently in the journal Cell.

New algorithm calculates drug synergy; initial tests involve melanoma, lung cancer

Monday, February 25th, 2019

Drug combinations used for the treatment of non-small-cell lung cancer (NSCLC) and melanoma aren’t as effective as they could be. That could change with a new algorithm developed by a cross-disciplinary Vanderbilt University team for calculating drug synergy.

Discovery points to new cancer immunotherapy option

Monday, February 25th, 2019

Researchers have discovered that a new “checkpoint” protein on immune system cells is active in tumors, and that blocking it — in combination with other treatments — is a successful therapeutic approach in mouse models of cancer.

The yin and yang of cell signaling

Thursday, February 14th, 2019

Changes in enzymes involved in lysophospholipid signaling can activate a pathway implicated in development of cancer, a recent study suggests.

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