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News: Signal Transduction and Chemical Biology Research Program

Gene network for leukemia factor

Thursday, February 4th, 2021

Transcription factors — proteins that regulate gene expression — play critical roles in cell fate decisions and are frequent targets of mutation in a variety of human cancers.

An interacting factor in leukemia

Monday, January 25th, 2021

TG-Interacting Factor 1 (TGIF1) is a protein that regulates self-renewal of hematopoietic stem cells, which give rise to other blood cells, and which affects proliferation and differentiation of myeloid cells.

The plus and minus of microtubules

Friday, September 6th, 2019

Understanding the dynamic regulation of cytoskeletal microtubules may suggest new ways to treat disorders ranging from Alzheimer’s disease to cancer.

A “rheostat” for cancer signals

Friday, August 30th, 2019

Jason MacGurn and colleagues have characterized a “rheostat” that sets WNT pathway signaling in breast cancer cells.

Study details regulation of a multi-drug transporter

Thursday, May 30th, 2019

Vanderbilt University researchers have discovered how a protein pump distinguishes between chemicals that it will expel from a cell and inhibitors that block its action – findings that could guide the development of more efficient inhibitors to prevent cancer cell resistance to chemotherapy.

Cancer Center’s annual scientific retreat set for May 1

Thursday, April 25th, 2019

The 20th Annual Scientific Retreat will be held Wednesday, May 1, 8:30 a.m. to 3 p.m., at the Vanderbilt University Student Life Center. Registration is free, but attendees should register by April 26. The topic of the retreat is “Signal Transduction in Cancer Initiation, Progression and Treatment.”

Like racecars and geese, cancer cells draft their way to new tumor sites

Friday, April 5th, 2019

Finding gives boost to fighting cancer through cell metabolism

Cancer’s SOS

Thursday, April 4th, 2019

Uncontrolled activation of RAS causes approximately a third of all tumors and helps cancerous cells evade anti-cancer drugs. Vanderbilt researchers have identified small molecules that target this pathway and further defined how these small molecule compounds work.

The yin and yang of cell signaling

Thursday, February 14th, 2019

Changes in enzymes involved in lysophospholipid signaling can activate a pathway implicated in development of cancer, a recent study suggests.

Signals from the “conveyor belt”

Friday, January 18th, 2019

Carlos F. Lopez, PhD, and colleagues propose a new “conveyor belt” mechanism for how cellular signaling is amplified, or strengthened, as signals are handed off from one enzyme to the next.

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