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News: Signal Transduction and Chemical Biology Research Program

The yin and yang of cell signaling

Thursday, February 14th, 2019

Changes in enzymes involved in lysophospholipid signaling can activate a pathway implicated in development of cancer, a recent study suggests.

Signals from the “conveyor belt”

Friday, January 18th, 2019

Carlos F. Lopez, PhD, and colleagues propose a new “conveyor belt” mechanism for how cellular signaling is amplified, or strengthened, as signals are handed off from one enzyme to the next.

The exocyst dynamo

Friday, December 14th, 2018

A recent study in Nature Communications reveals new insights about the function of the exocyst – a crucial cellular protein complex involved in vesicle trafficking.

Evading cell death

Monday, November 12th, 2018

A recent study reveals how cellular structures called ‘stress granules’ help cells evade death. The findings may lead to new strategies for improving the efficacy of cancer therapy.

Cancer Moonshot award to help map tumor progression

Thursday, September 27th, 2018

A trans-institutional team of researchers at Vanderbilt University Medical Center and Vanderbilt University has received an $11 million Cancer Moonshot grant to build a single-cell resolution atlas to map out the routes that benign colonic polyps take to progress to colorectal cancer.

Energetic gene switch

Tuesday, September 4th, 2018

Vanderbilt researchers have identified a previously undetected type of histone modification that may have implications for cancer and other conditions.

A brain-builder called “Shh”

Tuesday, September 4th, 2018

The Sonic hedgehog protein plays a crucial role in the development of brain cells that may be the source of some types of pediatric brain tumors, a recent study reports.

Fueling the MATE transporter

Friday, August 3rd, 2018

A recent study on how cellular proteins known as “multidrug transporters” work may inform the development of novel anti-cancer and anti-bacterial drugs that can overcome resistance.

Study tracks protein’s role in stem cell function

Thursday, March 22nd, 2018

Many types of cancer cells escape the body’s effort to kill them by overexpressing MCL-1, a protein important for blocking apoptosis, or programmed cell death. A recent study by Vivian Gama, PhD and colleagues indicates that MCL-1 also helps maintain the identity and ability of stem cells to differentiate, or give rise to other kinds of cells. 

Boehringer Ingelheim and Vanderbilt University expand partnership to develop novel treatment approaches for cancer

Thursday, March 22nd, 2018

Boehringer Ingelheim and Vanderbilt University recently announced the expansion of their successful existing collaboration to develop novel anti-cancer compounds.

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