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News: Translational Research and Interventional Oncology Research Program

Childhood cancer: how it’s different than for adults

Saturday, June 29th, 2019

The nature of childhood cancer is different than adult cancer, and so is the approach to treatment.

Cardiac toxicity risk factors identified with relapsed multiple myeloma therapy

Saturday, June 29th, 2019

More than half of patients with relapsed multiple myeloma treated with carfilzomib experienced cardiac issues during treatment, according to a multi-institutional study published June 12 in the Journal of Clinical Oncology.

Treatment approved for patients with acute graft-versus-host disease

Saturday, June 29th, 2019

The U.S. Food and Drug Administration (FDA) recently approved ruxolitinib, the first drug for patients with acute graft-versus-host disease (GVHD) who have an inadequate response to steroid treatment.

Immunotherapy helping 87-year-old man stay on the job

Friday, June 7th, 2019

Immunotherapy is helping cancer patient Roszell Mack Jr. to continue going to his job on a Kentucky horse farm.

Pathways of radiosensitization

Thursday, April 25th, 2019

Austin Kirschner, MD, PhD, and colleagues have studied the mechanism of radiation sensitization for enzalutamide using multiple models of human prostate cancer.

Study reframes approach to targeted therapy resistance

Thursday, April 25th, 2019

A recent study provides clinicians genomic guidance for surveillance of targeted therapy resistance in patients with EGFR-mutant non-small cell lung cancer — and more importantly — another drug option when resistance occurs.

Achilles’ heel for kidney cancer

Monday, March 4th, 2019

A recent study found that renal cell carcinoma cells with mutations in an enzyme-encoding gene, SETD2, were sensitive to a drug that inhibits the enzyme PI3K-beta.

Investigators map genomic landscape of very rare cancer

Monday, March 4th, 2019

Vanderbilt researchers have mapped out the genomic landscape of a metastatic malignant proliferating tricholemmal tumor and identified a targeted treatment for this very rare cancer.

New algorithm calculates drug synergy; initial tests involve melanoma, lung cancer

Monday, February 25th, 2019

Drug combinations used for the treatment of non-small-cell lung cancer (NSCLC) and melanoma aren’t as effective as they could be. That could change with a new algorithm developed by a cross-disciplinary Vanderbilt University team for calculating drug synergy.

AHA statement supports vascular cardio-oncology

Monday, February 25th, 2019

The American Heart Association (AHA) has issued a scientific statement calling for the integration of cardio-oncology and vascular medicine to provide cancer patients and cancer survivors with optimal cardiovascular care.

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