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News: Neil Osheroff

‘Detangler’ Binds, Bends and Cuts DNA

Friday, March 2nd, 2012

When the double-stranded “rope” of DNA is unwound to be copied, it can become knotted or tangled. The enzyme topoisomerase II detangles DNA by cutting both strands, removing the tangles, and stitching the DNA back together. Because breaks in the DNA can lead to genetic mutations and cell death, topoisomerase II is a target of […]