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    News: NIH

    Ancestry Impacts Smoking Risk for Lungs

    Wednesday, August 8th, 2012

    Smoking tobacco reduces lung function. African Americans have lower lung function compared to European Americans, but it is unclear if African ancestry modifies smoking’s impact on lung function. Melinda Aldrich, Ph.D., MPH, assistant professor of Thoracic Surgery, and colleagues evaluated lung function, tobacco smoking exposure and genetic ancestry in a large population of African Americans who […]

    Gene Database to Aid Disease Research

    Wednesday, June 13th, 2012

    Next generation sequencing (NGS) has dramatically accelerated the discovery of disease-associated genetic variants. Also known as massively parallel sequencing, this technological tour de force can rapidly “read” a sequence of DNA bases (the “letters” in our genomes) in parallel, making genome sequencing feasible in the research lab. Vanderbilt researchers have developed a “catalog” of human […]

    Roots of Childhood Brain Tumors

    Wednesday, June 13th, 2012

    Identifying the cellular origins of medulloblastoma – the most common malignant brain tumor in children – may help focus treatment on cell types responsible for tumor initiation. Previous research has linked Sonic hedgehog signaling in neuronal cell precursors within the developing cerebellum to medulloblastoma. Now, Chin Chiang, Ph.D., and colleagues demonstrate that “turning on” Sonic […]

    Protein Family Linked to Suppressing Tumors

    Friday, October 28th, 2011

    The list of aging-associated proteins known to be involved in cancer is growing longer, according to research by investigators at Vanderbilt-Ingram Cancer Center and the National Institutes of Health (NIH). The new study, published Oct. 17 in Cancer Cell, identifies the protein SIRT2 as a tumor suppressor linked to gender-specific tumor development in mice. Along […]