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    News: Pran Datta

    Smoking Stokes Cells’ Cancer Capacity

    Friday, March 16th, 2012

    Smoking contributes to the vast majority (around 85 percent) of lung cancer cases. The TGF-beta signaling pathway – which regulates cell growth and proliferation – is altered in several cancer types, but little is known about how smoking affects this pathway. To investigate this, Debangshu Samanta, Pran Datta, Ph.D., and colleagues exposed human lung epithelial […]

    Drugs Reverse Lung Cancer Cell Changes

    Friday, February 3rd, 2012

    The protein transforming growth factor β (TGF-β) can act as either a tumor suppressor or a tumor promoter depending on the stage of cancer. Loss of TGF-β’s tumor suppressor activity may play an important role in lung cancer progression. Pran Datta, Ph.D., and colleagues previously showed that this loss of responsiveness to TGF-β occurs mainly […]