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News: protein

iPOND Method Goes Fishing for Proteins

Friday, March 16th, 2012

Understanding DNA replication and DNA damage responses – which must proceed faithfully to prevent diseases such as cancer – requires the ability to monitor protein dynamics at active and damaged replication forks (sites of DNA duplication). Existing methods for studying replication fork machinery have been limited in resolution and sensitivity. Now, David Cortez, Ph.D., and […]

Protein Loss Sets Up Pro-Tumor State

Friday, July 15th, 2011

Breakdown of the gut lining is associated with inflammatory bowel disorders and colon cancer. Previously, Albert Reynolds, Ph.D., and colleagues showed that the protein p120 helps maintain integrity of the gut lining in mice and its loss may play a role in inflammatory bowel disorders. However, these mice did not survive long enough to investigate […]